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Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

• Lavinia Stingl, Thorsten Stuehmer, M. Chatterjee, M. R. Jensen, Michael Flentje, Cholpon S. Djuzenova
• British Journal of Cancer
• 2010

Background:Heat-shock protein 90 (Hsp90) has a crucial role in both the stabilisation and regulation of various proteins, including those related to radioresistance. Inhibition of Hsp90 may therefore… (More)

Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma

• Thorsten Stuehmer, Angela Zöllinger, +13 authors Ralf C Bargou
• Leukemia
• 2008

We as well as others have recently shown that Hsp90 is overexpressed in multiple myeloma (MM) and critically contributes to tumour cell survival. Pharmacologic blockade of Hsp90 has consistently been… (More)

Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells.

• Joyce J. Hwa, Lorraine Ghibaudi, +4 authors Edmund J. Sybertz
• Circulation research
• 1996

The thrombin receptor was the first cloned G protein-coupled receptor reported to be activated by proteolytic cleavage of its extracellular amino terminus. A second proteinase-activated receptor… (More)

Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony.

• Gunjan Mandal, Sarah A Wyllie, N. Singh, S. Sundar, Alan H. Fairlamb, M. Chatterjee
• Parasitology
• 2007

The current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied… (More)

Identification and purification of cytolytic antibodies directed against O-acetylated sialic acid in childhood acute lymphoblastic leukemia.

• S. Pal, M. Chatterjee, Debdutta Bhattacharya, Sivaji Bandhyopadhyay, Chandi Charan Mandal
• Glycobiology
• 2000

Sialic acids typically present as terminal sugars of oligo-saccharides are reported to be modified by O-acetylation at the C-9 position on lymphoblasts of childhood acute lymphoblastic leukemia (ALL)… (More)

Investigation of 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukaemia.

• Chandi Charan Mandal, M. Chatterjee, D. Sinha
• British journal of haematology
• 2000

An Economic Framework for Spectrum Allocation and Service Pricing with Competitive Wireless Service Providers

• S. Sengupta, M. Chatterjee, S. Ganguly
• 2007 2nd IEEE International Symposium on New…
• 2007

In the future, we can expect to see more dynamic service offerings and profiles, as users move from long-term service provider agreements to more opportunistic service models. Moreover, when the… (More)

Vitamin D and genomic stability.

• M. Chatterjee
• Mutation research
• 2001

1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been shown to act on novel target tissues not related to calcium homeostasis. There have been reports characterizing 1,25(OH)(2)D(3) receptors… (More)

A novel effect of selenium on streptozotocin-induced diabetic mice.

• R. Ghosh, B. Mukherjee, M. Chatterjee
• Diabetes research
• 1994

The effect of oral administration of sodium selenite on glucose homoeostasis was studied in male Swiss albino mice 6 weeks after they were made diabetic with streptozotocin. Diabetes caused… (More)

Calcium-dependent stress maintenance without myosin phosphorylation in skinned smooth muscle.

• M. Chatterjee, R. A. Murphy
• Science
• 1983

Stress development depended on calcium-stimulated myosin phosphorylation in an arterial smooth muscle preparation in which the concentration of calcium was controlled. However, developed stress was… (More)

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