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Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1.
TLDR
HL is established as a major modulator of SR-BI mediated selective uptake of HDL-CE via the newly described scavenger receptor BI, which is mediated by both its ligand role, which requires interaction with proteoglycans, and by lipolysis with subsequent HDL particle remodeling. Expand
Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice*
TLDR
It is concluded that CETP expression reduces atherosclerosis in LCAT-Tg mice by restoring the functional properties of LCAT/Tg mouse HDL and promoting the hepatic uptake of HDL-CE. Expand
Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice.
TLDR
The concept that hepatic lipase (HL) may serve as a ligand that mediates the interaction between remnant lipoproteins and cell surface receptors and/or proteoglycans in apoE-deficient mice is supported. Expand
Molecular cloning and expression of murine thromboxane synthase.
TLDR
The complementary DNA (cDNA) for murine thromboxane synthase (TS) was isolated from a lung cDNA library and confirmed by transient expression of a catalytically active TS in cos-1 cells, suggesting a shorter 5' untranslated region and/or poly (A) tail in the kidney transcript. Expand
BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene
ABSTRACT In earlier studies we identified a putative repressor of the human β-globin gene, termed beta protein 1 (BP1), which binds to two silencer DNA sequences upstream of the adult human β-globinExpand
Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization.
TLDR
The potent effect of TxA2 on platelet function and vascular activity suggests a possible involvement of TS in normal and pathophysiological conditions such as cardiovascular disease. Expand
Binding of HMG‐I(Y) elicits structural changes in a silencer of the human β‐globin gene
TLDR
A model in which HMG‐I(Y) alters DNA conformation to allow binding of repressor proteins, and in which the relative amount of H MG‐I (Y) helps to determine the repressive state of the β‐globin gene is presented. Expand
BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.
In earlier studies we identified a putative repressor of the human beta-globin gene, termed beta protein 1 (BP1), which binds to two silencer DNA sequences upstream of the adult human beta-globinExpand