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Indoor allergens and asthma: report of the Third International Workshop.
TLDR
The Third International Workshop on Indoor Allergens and Asthma was designed to discuss recent progress in basic and clinical research in this area, to formulate recommendations for allergen-specific management of asthma, and to consider future research directions.
A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I.
TLDR
The Mab ELISA will be useful in epidemiological studies of allergic asthma, both in the assessment of levels of dust miteAllergen present in houses and the efficacy of allergen avoidance regimes.
Mite faeces are a major source of house dust allergens
TLDR
Measurements from a radioimmunoassay show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.
Allergen immunotherapy: therapeutic vaccines for allergic diseases
TLDR
This poster presents a probabilistic procedure to quantify the immune response of the immune cells to polypeptide A, a substance that damages the immune system through contact chemoreception and excites the immuneocytes.
Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins
TLDR
The results suggest that Asp fI could play a dual role in the pathogenesis of A. fumigatus-related diseases by promoting colonization through cytotoxic activity and by causing inflammatory reactions involving IgE antibodies.
BASOPHILS IN ALLERGEN-INDUCED PATCH TEST SITES IN ATOPIC DERMATITIS
TLDR
Patch testing for 48 h at superficially abraded skin sites revealed that allergens could induce eczematous lesions in atopic dermatitis patients but only in those who also gave a positive immediate skin reaction to the same allergen.
Nomenclature and structural biology of allergens.
TLDR
Allergens are derived from proteins with a variety of biologic functions, including proteases, ligand- binding proteins, structural proteins, pathogenesis-related proteins, lipid transfer proteins, profilins, and calcium-binding proteins.
Novel Allergen Structures with Tandem Amino Acid Repeats Derived from German and American Cockroach*
TLDR
The molecular cloning of three Bla’g’1 cDNA clones showed 70% amino acid sequence identity with Per’a 1, and the repeat sequences appear to have evolved by duplication of an ancestral amino acid domain, which may have arisen from the mitochondrial energy transfer proteins.
Dust mites: immunology, allergic disease, and environmental control.
Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital.
TLDR
There was a strong inverse relationship between IgE antibodies to cat and to cockroach, and the risk of this sensitization was in large part restricted to homes or areas with high levels of allergen.
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