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ISfinder: the reference centre for bacterial insertion sequences
- P. Siguier, J. Pérochon, L. Lestrade, J. Mahillon, M. Chandler
- Biology, Computer Science
- Nucleic Acids Res.
- 28 December 2005
This database is currently recommended by several microbiology journals for registration of new IS elements before their publication and is involved in annotating the IS content of these genomes. Expand
This review presents a general overview of the organization and function of insertion sequences of eubacterial, archaebacterial, and eukaryotic origins with particular emphasis on bacterial elements and on different aspects of the transposition mechanism. Expand
Genome sequence of the plant pathogen Ralstonia solanacearum
The complete genome sequence and its analysis of strain GMI1000 suggests that bacterial plant pathogens and animal pathogens harbour distinct arrays of specialized type III-dependent effectors. Expand
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens
Compared with the genomes of related bacteria, the complete genome sequence of strain TT01 reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen. Expand
Insertion Sequences revisited
A general pattern for the functional organization of Tpases appears to be emerging from the limited number that have been analyzed, and one general feature of IS elements is that, on insertion, most generate short directly repeated sequences of the target DNA flanking the IS. Expand
Insertion sequences in prokaryotic genomes.
This work has shown that defective (non- autonomous) elements, which can be complemented by related active elements in the same cell, are often overlooked in genome annotations but also contribute to the evolution of genome organisation. Expand
Bacterial insertion sequences: their genomic impact and diversity
This review focuses on prokaryotic ISs, and explains how ISs are identified and classified into families by a combination of characteristics including their transposases (Tpases), their overall genetic organisation and the accessory genes which some ISs carry. Expand
ISsaga is an ensemble of web-based methods for high throughput identification and semi-automatic annotation of insertion sequences in prokaryotic genomes
- A. Varani, P. Siguier, Edith Gourbeyre, Vincent Charneau, M. Chandler
- Biology, Medicine
- Genome Biology
- 28 March 2011
A web application pipeline, ISsaga, that provides computational tools and methods for high-quality IS annotation, which uses established ISfinder annotation standards and permits rapid processing of single or multiple prokaryote genomes. Expand
Breaking and joining single-stranded DNA: the HUH endonuclease superfamily
- M. Chandler, F. Cruz, F. Dyda, A. Hickman, G. Moncalián, B. Ton-Hoang
- Biology, Medicine
- Nature Reviews Microbiology
- 1 August 2013
An overview of these fascinating enzymes and their functions is provided, using well-characterized examples of Rep proteins, relaxases and transposases, and the molecular mechanisms used in their diverse activities are explored. Expand
Regulation of transposition in bacteria.
An overview of the large range of regulatory mechanisms adopted by Transposable elements, which include mechanisms intrinsic to the element at the level of gene expression, the presence of key checkpoints in the recombination pathway and the intervention of host proteins which provide a TE/host interface are presented. Expand