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Mutations of polycomb‐associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
TLDR
The results show that ASXL1 might play the role of a tumour suppressor in myeloid malignancies, a disease classified as MDS/Myeloproliferative disorder. Expand
Integrated profiling of basal and luminal breast cancers.
TLDR
It is shown that gain of 10p is a new alteration in basal breast cancer and that a subregion of the 8p12 amplification is specific of luminal tumors, which supports the existence of specific oncogenic pathways in basal and luminal breast cancers. Expand
Mutations of ASXL1 gene in myeloproliferative neoplasms
TLDR
It is confirmed that epoxomicin-based compounds may be subject to this type of resistance mechanism and the first report to demonstrate the acquisition of P-gP with a proteasome inhibitor is demonstrated. Expand
Prognostic and predictive value of PDL1 expression in breast cancer
TLDR
PDL1 upregulation, more frequent in basal breast cancers, was associated with increased T-cell cytotoxic immune response and better survival and response to chemotherapy, and reactivation of dormant tumor-infiltrating lymphocytes by PDL1-inhibitors could represent promising strategy. Expand
Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
TLDR
A comprehensive study combining genomic, expression, and chromosome break analyses of the 8p11-12 region in breast cell lines and primary breast tumors shows that 8p 11-12 amplification has a pejorative effect on survival in breast cancer. Expand
Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers
TLDR
The results establish the frequencies, prognostic impacts and subtype associations of various amplifications and co-amplifications in breast cancers. Expand
Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer
TLDR
The data suggest that ECRG4 is a candidate TSG in breast cancer, the expression of which may help improve the prognostication, if functional analyses confirm this TSG role. Expand
ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia
TLDR
Mutations of ASXL1 correlated with an evolution toward an acutely transformed state: all CMMLs that progressed to acute phase were mutated and none of the unmutated patients had evolved to acute leukaemia. Expand
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
TLDR
NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukaemia with a normal karyotype. Expand
ZNF703 gene amplification at 8p12 specifies luminal B breast cancer
TLDR
It is shown that amplification of the ZNF703 gene, located in chromosomal region 8p12, preferentially occurs in luminal B tumours, and the prominent role of Z NF703 in transcription modulation, stem cell regulation and luminals B oncogenesis is pointed out. Expand
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