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Antifungal and Antibacterial Activity of the Newly Synthesized 2‐Xanthone Derivatives
A series of 2‐substituted xanthone derivatives 8–20 containing selected allyl, cinnamyl, morpholine, and imidazole moieties were synthesized and tested for their antifungal and antibacterial in‐vitro properties, showing significant efficacy against evaluated yeasts and dermatophytes. Expand
Changes in the cannabinoids receptors in rats following treatment with antidepressants
Results provide clear evidence that the antidepressant exposures provoke some modulations within the eCB system through CB receptors, particularly in cortical structures and hippocampal areas. Expand
4,6-Di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as New, Potent 5-HT2A Receptor Ligands: A Verification of the Topographic Model
A series of new 4,6-di(heteroaryl)pyrimidines containing an N-methylpiperazino group (6-13) or an ethylenediamine chain (15-20) in position 2 were synthesized and their 5-HT1A and 5-HT2A receptorExpand
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
The results of the quantitative structure-activity relationship analyses, including several classical, linear regression correlations and a Free-Wilson approach of de novo model, provide guidelines for the design of new active compounds of this class. Expand
Structure-activity relationship studies of CNS agents. Part 9: 5-HT1A and 5-HT2 receptor affinity of some 2- and 3-substituted 1,2,3,4-tetrahydro-beta-carbolines.
It has been shown by means of molecular modelling methods that pharmacophores of all the active compounds can adopt a common position at the 5-HT1A receptor model and offers an explanation for the observed stereoselectivity chiral compounds. Expand
Preliminary evaluation of pharmacological properties of some xanthone derivatives.
The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures. Expand
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone.
Results were quite promising and suggested that in the group of xanthone derivatives new potential antiarrhythmics and hypotensives might be found. Expand
Synthesis and Evaluation of Some Xanthone Derivatives for Anti‐Arrhythmic, Hypotensive Properties and Their Affinity for Adrenergic Receptors
Binding studies are in agreement with the pharmacological results and could explain anti‐arrhythmic effect of compound 15 and anti-arrhythmmic and hypotensive effects of compounds 9 and 12. Expand
Antiarrhythmic and antihypertensive activity of some xanthone derivatives.
Compounds II and IV were evaluated for anticonvulsant activity in the maximal electroshock seizures (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX) and the influence of investigated compounds on ECG components suggests that activity of compound IV is similar to class 1a anti-arrhythmic compounds according to Voughan-Williams classification of antiarrhythmmic drugs. Expand
Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone.
Results were quite encouraging and suggested that in the group of xanthone derivatives new potential anticonvulsants might be found. Expand