The capsaicin receptor: a heat-activated ion channel in the pain pathway
- M. Caterina, M. Schumacher, M. Tominaga, Tobias A. Rosen, J. Levine, D. Julius
- 22 October 1997
The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
The vanilloid receptor: a molecular gateway to the pain pathway.
The analysis of vanilloid receptor gene knockout mice confirms the involvement of this channel in pain sensation, as well as in hypersensitivity to noxious stimuli following tissue injury, and demonstrates the existence of redundant mechanisms for the sensation of heat-evoked pain.
A capsaicin-receptor homologue with a high threshold for noxious heat
It is proposed that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities.
Heat-Evoked Activation of the Ion Channel, TRPV4
- A. D. Güler, Hyosang Lee, T. Iida, I. Shimizu, M. Tominaga, M. Caterina
- BiologyJournal of Neuroscience
- 1 August 2002
It is demonstrated that another member of the TRP family, TRPV4, previously described as a hypo-osmolarity-activated ion channel, also can be activated by heat and observed TRPv4 immunoreactivity in anterior hypothalamic structures involved in temperature sensation and the integration of thermal and osmotic information, which implicate TRpV4 as a possible transducer of warm stimuli within the hypothalamus.
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
- M. Caterina
- BiologyAmerican Journal of Physiology. Regulatory…
The identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family.
Mechanisms of sensory transduction in the skin
It is now clear that perception of a single stimulus, such as heat, requires several transduction mechanisms, and how the skin's sensory functions are divided among signalling molecules and cell types is understood.