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The capsaicin receptor: a heat-activated ion channel in the pain pathway
The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Expand
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Expand
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
It is shown that protons decrease the temperature threshold for VR1 activation such that even moderately acidic conditions (pH < or = 5.9) activate VR1 at room temperature, and VR1 can be viewed as a molecular integrator of chemical and physical stimuli that elicit pain. Expand
The vanilloid receptor: a molecular gateway to the pain pathway.
The analysis of vanilloid receptor gene knockout mice confirms the involvement of this channel in pain sensation, as well as in hypersensitivity to noxious stimuli following tissue injury, and demonstrates the existence of redundant mechanisms for the sensation of heat-evoked pain. Expand
A capsaicin-receptor homologue with a high threshold for noxious heat
It is proposed that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities. Expand
Heat-Evoked Activation of the Ion Channel, TRPV4
It is demonstrated that another member of the TRP family, TRPV4, previously described as a hypo-osmolarity-activated ion channel, also can be activated by heat and observed TRPv4 immunoreactivity in anterior hypothalamic structures involved in temperature sensation and the integration of thermal and osmotic information, which implicate TRpV4 as a possible transducer of warm stimuli within the hypothalamus. Expand
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium. Expand
Mechanisms of sensory transduction in the skin
It is now clear that perception of a single stimulus, such as heat, requires several transduction mechanisms, and how the skin's sensory functions are divided among signalling molecules and cell types is understood. Expand
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
  • M. Caterina
  • Chemistry, Medicine
  • American journal of physiology. Regulatory…
  • 2007
The identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family. Expand
TRPV1 shows dynamic ionic selectivity during agonist stimulation
The qualitative signaling properties of TRpV1 are dynamically modulated during channel activation, a process that probably shapes TRPV1 participation in pain, cytotoxicity and neurotransmitter release. Expand