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The endogenous cannabinoid system controls extinction of aversive memories
Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction, and proposes that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala. Expand
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
- T. Bisogno, F. Howell, +11 authors P. Doherty
- Biology, Medicine
- The Journal of cell biology
- 10 November 2003
The cloning and enzymatic characterization of the first specific sn-1 DAG lipases are reported, providing a possible explanation for a fundamental change in endocannabinoid function during brain development. Expand
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
The endogenous cannabinoid system provides on-demand protection against acute excitotoxicity in central nervous system neurons and could not be triggered in mutant mice. Expand
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
- S. González, M. Cascio, J. Fernández-Ruiz, F. Fezza, V. Marzo, J. Ramos
- Medicine, Chemistry
- Brain Research
- 1 November 2002
Examining changes in the brain contents of arachidonoylethanolamide and 2-arachidonoyl-glycerol, the endogenous ligands for cannabinoid receptors, in animals chronically exposed to cocaine, nicotine or ethanol indicates that the three drugs tested here produce different changes in endocannabinoid transmission. Expand
Possible endocannabinoid control of colorectal cancer growth.
Endocannabinoid levels are enhanced in transformed colon mucosa cells possibly to counteract proliferation via CBRs, and inhibitors of endocannabinoids inactivation may prove useful anticancer agents. Expand
The endocannabinoid system: a general view and latest additions
The latest ‘additions’ to the endocannabinoid system are reviewed together with earlier breakthroughs that have contributed to the present knowledge of the biochemistry and pharmacology of theendocannabinoids. Expand
Endocannabinoids as physiological regulators of colonic propulsion in mice.
Endocannabinoids acting on myenteric CB1 receptors tonically inhibit colonic propulsion in mice, and high amounts of 2-arachidonylglycerol and particularly anandamide were found in the colon, together with a high activity of an andamide amidohydrolase. Expand
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.
- T. Bisogno, M. Cascio, +8 authors V. Di Marzo
- Biology, Medicine
- Biochimica et biophysica acta
- 1 February 2006
The first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid are reported. Expand
Novel bioactive metabolites of dipyrone (metamizol).
- T. Rogosch, Christian Sinning, +8 authors P. Imming
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
The arachidonoyl amides were positively tested for cannabis receptor binding and cyclooxygenase inhibition and suggest that the endogenous cannabinoid system may play a role in the effects of dipyrone against pain. Expand
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
The findings suggest that the expression of cannabinoid receptors and of FAAH in some tumour cells could well influence the effectiveness of DHA and EPA or their ethanolamide derivatives as anticancer agents. Expand