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Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection.
- A. Hector, H. Schäfer, D. Hartl
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 15 April 2015
Modulation of Tregs represents a novel strategy to rebalance T-cell responses, dampen inflammation, and ultimately improve outcomes for patients with infective CF lung disease.
Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells
In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency
To the Editor: Genome editing using a variety of different nucleases holds great potential to knock out or repair disease-causing genes. An ideal nuclease delivery vehicle is short-lived, does not…
Current concepts of immune dysregulation in cystic fibrosis.
Pseudomonas aeruginosa Airway Infection Recruits and Modulates Neutrophilic Myeloid-Derived Suppressor Cells
It is demonstrated, using an airway in vivo infection model, that P. aeruginosa recruits and activates neutrophilic MDSCs, which functionally suppress T-cell responses, and it is shown that the CF gene defect modulates the functionality, but not the recruitment or generation of neutrophobic M DSCs.
The chemokine CCL18 characterises Pseudomonas infections in cystic fibrosis lung disease
CCL18 levels characterise chronic P. aeruginosa infection and pulmonary obstruction in patients with CF and may, thus, serve as a potential biomarker and therapeutic target in CF lung disease.
CXCR1 and CXCR2 haplotypes synergistically modulate cystic fibrosis lung disease
CXCR1 and CXCR2 genotypes modulate lung function and antibacterial host defence in CF lung disease, and strongly correlated with age-adjusted lung function in CF patients.
mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo
Treatment with combinations of Tlr1, Tlr2 and Tlr6 mRNA in a House Dust Mite-induced mouse model of asthma resulted in better lung function as well as reduced airway inflammation in vivo, pointing to a potentially protective effect of TLR heterodimers in asthma pathogenesis.
The effects of benzo(a)pyrene on rat liver lysosomes.
An Interactive Network of Elastase, Secretases, and PAR-2 Protein Regulates CXCR1 Receptor Surface Expression on Neutrophils*
A novel functional network of elastase, secretases, and PAR-2 that regulate CXCR1 expression on neutrophils is established, which could lead to novel therapeutic approaches in neutrophilic diseases, such as cystic fibrosis or rheumatoid arthritis.