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Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma.
BACKGROUND & AIMS Early detection of hepatocellular carcinoma (HCC) is critical for successful treatment. However, the differential diagnosis between HCC and benign hepatic lesions is sometimes… Expand
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and GPC3 null mice display developmental overgrowth.… Expand
Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosyl-phosphatidylinositol anchor. GPC3 is expressed by most hepatocellular carcinomas but not by normal… Expand
Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling
Binding between the Hedgehog ligand and its receptor Patched 1 is stabilized by Glypican-5.
SummaryGlypicans are heparan sulfate proteoglycans that are bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor. Homologs of glypicans are found throughout the… Expand
Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo
- S. Zittermann, M. Capurro, W. Shi, J. Filmus
- Chemistry, Biology
- International journal of cancer
- 1 May 2008
The heterogeneity of the molecular pathology of HCC poses a formidable obstacle to the development of non‐cytotoxic therapies. Several pro‐tumorigenic signaling pathways can be aberrantly activated… Expand
Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling
ABSTRACT Glypican-3 (GPC3) is a proteoglycan that is bound to the cell surface. It is expressed by most hepatocellular carcinomas (HCCs) but not by normal hepatocytes. GPC3 stimulates HCC growth by… Expand
Overgrowth of a mouse model of Simpson– Golabi–Behmel syndrome is partly mediated by Indian Hedgehog
Loss‐of‐function mutations of Glypican 3 (Gpc3) cause the Simpson–Golabi–Behmel overgrowth syndrome (SGBS), and developmental overgrowth is observed in Gpc3‐null mice, a mouse model for SGBS. We… Expand
The role of glypicans in Hedgehog signaling.
Glypicans (GPCs) are a family of proteoglycans that are bound to the cell surface by a glycosylphosphatidylinositol anchor. Six glypicans have been found in the mammalian genome (GPC1 to GPC6). GPCs… Expand
Processing by Convertases Is Not Required for Glypican-3-induced Stimulation of Hepatocellular Carcinoma Growth*
- M. Capurro, W. Shi, Shaifali Sandal, J. Filmus
- Biology, Medicine
- Journal of Biological Chemistry
- 16 December 2005
Glypicans are a family of heparan sulfate proteoglycans that are bound to the cell surface by a lipid anchor. Six members of this family have been identified in mammals (GPC1-GPC6). Glypicans act as… Expand