• Publications
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Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma.
BACKGROUND & AIMS Early detection of hepatocellular carcinoma (HCC) is critical for successful treatment. However, the differential diagnosis between HCC and benign hepatic lesions is sometimesExpand
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Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and GPC3 null mice display developmental overgrowth.Expand
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Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosyl-phosphatidylinositol anchor. GPC3 is expressed by most hepatocellular carcinomas but not by normalExpand
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Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling
Binding between the Hedgehog ligand and its receptor Patched 1 is stabilized by Glypican-5.
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Glypicans
SummaryGlypicans are heparan sulfate proteoglycans that are bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor. Homologs of glypicans are found throughout theExpand
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Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo
The heterogeneity of the molecular pathology of HCC poses a formidable obstacle to the development of non‐cytotoxic therapies. Several pro‐tumorigenic signaling pathways can be aberrantly activatedExpand
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Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling
ABSTRACT Glypican-3 (GPC3) is a proteoglycan that is bound to the cell surface. It is expressed by most hepatocellular carcinomas (HCCs) but not by normal hepatocytes. GPC3 stimulates HCC growth byExpand
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Overgrowth of a mouse model of Simpson– Golabi–Behmel syndrome is partly mediated by Indian Hedgehog
Loss‐of‐function mutations of Glypican 3 (Gpc3) cause the Simpson–Golabi–Behmel overgrowth syndrome (SGBS), and developmental overgrowth is observed in Gpc3‐null mice, a mouse model for SGBS. WeExpand
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The role of glypicans in Hedgehog signaling.
  • J. Filmus, M. Capurro
  • Biology, Medicine
  • Matrix biology : journal of the International…
  • 1 April 2014
Glypicans (GPCs) are a family of proteoglycans that are bound to the cell surface by a glycosylphosphatidylinositol anchor. Six glypicans have been found in the mammalian genome (GPC1 to GPC6). GPCsExpand
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Processing by Convertases Is Not Required for Glypican-3-induced Stimulation of Hepatocellular Carcinoma Growth*
Glypicans are a family of heparan sulfate proteoglycans that are bound to the cell surface by a lipid anchor. Six members of this family have been identified in mammals (GPC1-GPC6). Glypicans act asExpand
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