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Echinostome infection in green frogs (Rana clamitans) is stage and age dependent
Histopathological analysis supported the hypothesis that echinostome-induced tadpole mortality resulted from compromised renal function, and suggested that the timing of highest cercarial shedding can coincide with the most vulnerable stages of green frog tadpole development, which could significantly impact green frog survival in nature.
Anticoagulant repertoire of the hookworm Ancylostoma caninum.
A family of potent small protein anticoagulants from the hookworm Ancylostoma caninum termed AcAP is described, suggesting that the AcAPs are distantly related to the family of small protein serine protease inhibitors found in the nonhematophagous nematode Ascaris lumbricoides var.
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast
Enzymatic analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate (HPP) tautomerase activity of MIF and an allosteric binding site of AV411 and AV1013 is detected by NMR.
Ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor Xa.
Data suggest that AcAP, a specific inhibitor of factor Xa, is one of the most potent naturally occurring anticoagulants described to date.
A Leishmania Ortholog of Macrophage Migration Inhibitory Factor Modulates Host Macrophage Responses1
An ortholog of the cytokine, macrophage migration inhibitory factor, Lm1740MIF, which is produced by the obligate intracellular parasite, Leishmania major, shows significant structural homology with human MIF and inhibits the activation-induced apoptosis of macrophages.
Orthologs of macrophage migration inhibitory factor from parasitic nematodes.
Recent progress in the characterization of macrophage migration inhibitory factor orthologs from parasitic nematodes is described, and the roles of these molecules in parasite developmental biology and pathogenesis are discussed.
A novel family of anticoagulants from the saliva of Ixodes scapularis
Data indicate that the anticoagulant protein purified by HPLC, Salp9Pac and Salp14 are members of a family of novel coagulation protease inhibitors present in tick saliva, which raises the possibility that ticks may enhance their adaptive ability to cope with a wide spectrum of proteases, by transcribing such structurally related anticoAGulant proteins with different functions.
Epidemiology and Management of Infectious Diseases in International Adoptees
Data from published studies, along with the recent experience of the Yale International Adoption Clinic, suggest that the risk of serious infections in adoptees is low, although infections associated with institutionalization still occur commonly.
Structural and Functional Characterization of a Secreted Hookworm Macrophage Migration Inhibitory Factor (MIF) That Interacts with the Human MIF Receptor CD74*
Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the host immune
Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum.
Using in vitro assays and quantitative reverse transcriptase real-time PCR, a potential role for AceFAR-1 is suggested in hookworm biology, making it a potentially valuable target for drug and vaccine development.