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African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.
This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility.
Loci associated with skin pigmentation identified in African populations
It is shown that both dark and light pigmentation alleles arose before the origin of modern humans and that both light and dark pigmented skin has continued to evolve throughout hominid history.
Genetic origins of lactase persistence and the spread of pastoralism in Africa.
The Evolution of Human Genetic and Phenotypic Variation in Africa
Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa.
Striking patterns of variation are reported at TAS2R38, including a significant excess of novel rare nonsynonymous polymorphisms that recently arose only in Africa, high frequencies of haplotypes in Africa associated with intermediate bitter taste sensitivity, a remarkably similar frequency of common haplotypes across genetically and culturally distinct Africans, and an ancient coalescence time of common variation in global populations.
Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers
MiRNA expression profiles represent a promising new category of disease biomarkers, however, population specific genetic variation can affect the prevalence and baseline expression of these miRNAs in diverse populations.
Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana
Within two African populations, it is found that bacterial diversity per individual and within-population phylogenetic dissimilarity differs between Botswanan and Tanzanian populations, with Tanzania generally having higher diversity per Individual and lower Dissimilarity between individuals.
The peopling of the African continent and the diaspora into the new world.
Structure and expression of the cDNA for the C isozyme of phosphofructo-1-kinase from rabbit brain.
Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Striking signatures of positive selection are reported, including significant Fay and Wu's H statistics predominantly in East Africa, indicating strong local adaptation and greater genetic structure among African populations than expected under neutrality.