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Physiology of the prion protein.
TLDR
A unified view of functional properties of PrP(C) indicates that the prion protein is a dynamic cell surface platform for the assembly of signaling modules, based on which selective interactions with many ligands and transmembrane signaling pathways translate into wide-range consequences upon both physiology and behavior. Expand
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
TLDR
It is shown that 12 hr after acquisition of a one-trial associative learning task, there is a novel protein synthesis and BDNF-dependent phase in the rat hippocampus that is critical for the persistence of LTM storage. Expand
Dopamine Controls Persistence of Long-Term Memory Storage
TLDR
The persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points. Expand
BDNF is essential to promote persistence of long-term memory storage
TLDR
It is demonstrated that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis, and induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Expand
On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory.
TLDR
The results indicate that hippocampal protein synthesis is required during a limited post-training time window for consolidation of object recognition memory and show that the hippocampus is engaged during reconsolidation of this type of memory, maybe accruing new information into the original trace. Expand
BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation
TLDR
It is shown that consolidation of inhibitory avoidance LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GLUR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO). Expand
Different molecular cascades in different sites of the brain control memory consolidation
TLDR
Memory consolidation involves a complex network of brain systems and serial and parallel molecular events, even for a task as deceptively simple as one-trial avoidance, and is proposed that these molecular events might also be involved in many other memory types in animals and humans. Expand
Plastic modifications induced by object recognition memory processing
TLDR
It is shown that OR memory consolidation is accompanied by transient potentiation in the hippocampal CA3-CA1 synapses, while reconsolidation of this memory requires a short-lasting phase of depotentiation that could account for its well described vulnerability. Expand
mTOR signaling in the hippocampus is necessary for memory formation
TLDR
It is shown that LTM formation of one-trial inhibitory avoidance in rats, a hippocampus-dependent fear-motivated learning task, requires mTOR activation, and the regulation of hippocampal mRNA translation is a major control step in memory consolidation. Expand
Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade.
TLDR
Evidence is provided for the participation of hippocampal PKA/CREB and MAPK/Elk-1 pathways, via activation ofNMDA receptors, in memory formation of a one-trial avoidance learning in rats, and NMDA receptors appear to be a necessary upstream step for the activation of these intracellular cascades during learning. Expand
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