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Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions
Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the thirdExpand
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Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.
BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited itsExpand
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Improved gapped alignment in BLAST
TLDR
We propose a new step in the BLAST algorithm to reduce the computational cost of searching with negligible effect on accuracy, allowing BLAST to accurately filter sequences with lower computational cost. Expand
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A Deterministic Finite Automaton for Faster Protein Hit Detection in BLAST
TLDR
In this paper, we present an optimization to the first stage of the BLAST algorithm specifically designed for protein search. Expand
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An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription.
The human immunodeficiency virus type 1 (HIV) Tat protein, a potent activator of HIV gene expression, is essential for integrated viral genome expression and represents a potential antiviral target.Expand
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Improved Gapped Alignment in BLAST
TLDR
We propose a new step in the blast algorithm to reduce the computational cost of searching with negligible effect on accuracy, allowing blast to accurately filter sequences with lower computational cost. Expand
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Sleep and aggression in substance-abusing adolescents: results from an integrative behavioral sleep-treatment pilot program.
STUDY OBJECTIVE To examine whether change in total sleep time during an integrative, behavioral sleep intervention is associated with aggression. Specifically, we tested whether adolescents whoExpand
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Comparing Compressed Sequences for Faster Nucleotide BLAST Searches
TLDR
We propose two new, fast gapped alignment schemes that allow accurate sequence alignment without decompression of the collection sequences. Expand
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Christ Meets Me Everywhere: Augustine's Early Figurative Exegesis
Preface Abbreviations Introduction: Ask, Seek, Knock: Approaching Augustine's Figurative Reading Part I: Novice: Rhetor, Convert, Seeker of Wisdom (386-391) Chapter 1: Eureka! in Milan: When AmbroseExpand
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