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Long-Distance Retrograde Effects of Botulinum Neurotoxin A
Botulinum neurotoxins (designated BoNT/A–BoNT/G) are bacterial enzymes that block neurotransmitter release by cleaving essential components of the vesicle fusion machinery. BoNT/A, which cleavesExpand
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Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
Neurogenesis continues to occur in the adult mammalian hippocampus and is regulated by both genetic and environmental factors. It is known that exposure to an enriched environment enhances the numberExpand
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Evidence for Anterograde Transport and Transcytosis of Botulinum Neurotoxin A (BoNT/A)
Botulinum neurotoxin type A (BoNT/A) is a metalloprotease that blocks synaptic transmission via the cleavage of SNAP-25 (synaptosomal-associated protein of 25 kDa). BoNT/A is successfully used inExpand
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A Radial Glia-Specific Role of RhoA in Double Cortex Formation
The positioning of neurons in the cerebral cortex is of crucial importance for its function as highlighted by the severe consequences of migrational disorders in patients. Here we show that geneticExpand
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Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP
Elevated intraocular pressure may lead to retinal ganglion cell injury and consequent visual deficits. Chronic intraocular pressure increase is a major risk factor for glaucoma, a leading blindingExpand
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Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons
The striking differences between the clinical symptoms of tetanus and botulism have been ascribed to the different fate of the parental neurotoxins once internalised in motor neurons. Tetanus toxinExpand
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Synergistic Effects of Brain-Derived Neurotrophic Factor and Chondroitinase ABC on Retinal Fiber Sprouting after Denervation of the Superior Colliculus in Adult Rats
Damage to the adult CNS often causes devastating and permanent deficits because of the limited capacity of the brain for anatomical reorganization. The finding that collateral sprouting of uninjuredExpand
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AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2γ regulates laminar fate in aExpand
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Environmental enrichment potentiates thalamocortical transmission and plasticity in the adult rat visual cortex
It has been demonstrated that the complex sensorimotor and social stimulation achieved by rearing animals in an enriched environment (EE) can reinstate juvenile‐like plasticity in the adult cortex.Expand
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Functional Masking of Deprived Eye Responses by Callosal Input during Ocular Dominance Plasticity
Monocular deprivation (MD) is a well-known paradigm of experience-dependent plasticity in which cortical neurons exhibit a shift of ocular dominance (OD) toward the open eye. The mechanismsExpand
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