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Long-Distance Retrograde Effects of Botulinum Neurotoxin A
TLDR
It is demonstrated that catalytically active BoNT/A is retrogradely transported by central neurons and motoneurons and is then transcytosed to afferent synapses, in which it cleaves SNAP-25. Expand
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
TLDR
It is concluded that BDNF but not NT‐4 is required for the environmental induction of neurogenesis, and failure to up‐regulate BDNF accompanied the lack of a neurogenic response in enriched BDNF heterozygous mice. Expand
Evidence for Anterograde Transport and Transcytosis of Botulinum Neurotoxin A (BoNT/A)
TLDR
It is demonstrated that catalytically active BoNT/A is anterogradely transported from the eye to the SC and transcytosed to tectal synapses, which is important for a more complete understanding of the mechanisms of action of Bo NT/A. Expand
Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP
TLDR
Data show that rapid pressure transients induce acute ganglion cell injury and unveil the causal role of extracellular ATP elevation in such injury. Expand
A Radial Glia-Specific Role of RhoA in Double Cortex Formation
TLDR
It is shown that genetic deletion of the small GTPase RhoA in the developing cerebral cortex results in two migrational disorders: subcortical band heterotopia (SBH) and cobblestone lissencephaly, and defects in radial glial cells, rather than neurons, can be sufficient to produce SBH. Expand
AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
TLDR
It is found that the transcription factor AP2γ regulates laminar fate in a region-specific manner and acts as a regulator of basal progenitor fate, linking regional and lamination specification in the mouse developing cerebral cortex. Expand
Synergistic Effects of Brain-Derived Neurotrophic Factor and Chondroitinase ABC on Retinal Fiber Sprouting after Denervation of the Superior Colliculus in Adult Rats
TLDR
Treatments that promote the sprouting of undamaged retinal afferents into the denervated superior colliculus after a partial retinal lesion in the adult rat are characterized and suggest that the combined treatment with BDNF and C-ABC can be relevant in therapies for the repair of the damaged adult CNS. Expand
Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons
TLDR
Results suggest that the fast axonal retrograde transport compartment is composed of multifunctional trafficking organelles orchestrating the simultaneous transfer of diverse cargoes from nerve terminals to the soma, and represents a general gateway for the delivery of virulence factors and pathogens to the central nervous system. Expand
Functional Masking of Deprived Eye Responses by Callosal Input during Ocular Dominance Plasticity
TLDR
It is concluded that callosal inputs play a key role in functional weakening of less active connections during OD plasticity. Expand
Environmental enrichment potentiates thalamocortical transmission and plasticity in the adult rat visual cortex
TLDR
In the adult rat, EE enhances synaptic strength and plasticity of the thalamocortical pathway associated with specific changes in glutamatergic and GABAergic neurotransmission with novel insights into the mechanisms by which EE shapes the adult brain. Expand
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