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Structural and Functional Analyses of a Novel Ig-like Cell Adhesion Molecule, hepaCAM, in the Human Breast Carcinoma MCF7 Cells*
TLDR
The cytoplasmic domain of hepaCAM is essential to its function on cell-matrix interaction and cell motility, and is shown to co-localize with E-cadherin at the lateral membrane. Expand
The roles of cell adhesion molecules in tumor suppression and cell migration
TLDR
Paradoxically, in 2005, an immunoglobulin superfamily cell adhesion molecule hepaCAM was identified that is able to suppress cancer cell growth and yet induce migration, and CEACAM1 was verified to co-function as a tumor suppressor and invasion promoter. Expand
HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells.
TLDR
The data show that HEPN1 is frequently silenced in HCC, and that exogenous H EPN1 exhibits antiproliferative effect on HepG2 cells, suggesting that silencing of HEPn1 may be associated with carcinogenesis of hepatocytes. Expand
Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells.
TLDR
The results suggest that the expression of hepaCAM in MCF7 cells not only inhibits cell growth but also induces cellular senescence through the p53/21 pathway. Expand
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression.
TLDR
The results reveal a new regulatory mechanism for CD137L expression that mediates immune escape by HRS cells, and they identify CD137 as a candidate target for immunotherapy of Hodgkin lymphoma. Expand
HepaCAM associates with connexin 43 and enhances its localization in cellular junctions
TLDR
By discovering the requirement of hepaCAM for localizing connexin 43, a well-established tumor suppressor, to cellular junctions and stabilizing it there, this study suggests a mechanism by which deletion of hePACAM may support tumor progression. Expand
Molecular characterization of hepatitis B virus surface antigen mutants in Singapore patients with hepatocellular carcinoma and hepatitis B virus carriers negative for HBsAg but positive for anti‐HBs
TLDR
Mutations on the a‐determinant of hepatitis B virus surface antigen (HBsAg), capable of escaping detection and vaccination, are identified in HBsAg‐positive/anti‐HBs‐positive vaccinated infants and patients with hepatocellular carcinoma. Expand
Baseline predictors of aortic stiffness progression among multi-ethnic Asians with type 2 diabetes.
TLDR
It is demonstrated that baseline BMI is a modifiable independent risk factor of carotid-femoral pulse wave velocity progression and incident aortic stiffness among Singapore's multi-ethnic Asians with type 2 diabetes (T2DM), and better obesity management may impede aorti stiffness in Singapore's T2DM patients. Expand
The immunoglobulin‐like cell adhesion molecule hepaCAM modulates cell adhesion and motility through direct interaction with the actin cytoskeleton
TLDR
It is found that hepaCAM was partially insoluble in Triton X‐100 and colocalized with the actin cytoskeleton on the plasma membrane and deletion of either the extracellular or the cytoplasmic domain of he PaCAM abolished actin coprecipitation as well as delayed cell–ECM adhesion and cell motility. Expand
The immunoglobulin‐like cell adhesion molecule hepaCAM induces differentiation of human glioblastoma U373‐MG cells
TLDR
It is demonstrated that hepaCAM is capable of inducing differentiation of the human glioblastoma U373‐MG cells, and the degree of cell differentiation is dependent on the expression level of he PaCAM. Expand
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