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Comparison between oral and vaginal administration of misoprostol on uterine contractility.
The long-lasting and continuously increasing uterine contractility after vaginal administration can be explained only in part by a direct effect of misoprostol. Expand
Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up.
The results suggest that the fetal nigral implants may have provided a modest improvement in motor function, consistent with the presence of small surviving grafts, in two patients with advanced Parkinson's disease. Expand
Mid-trimester induced abortion: a review.
The aim of this article is to provide a review of the current literature of mid-trimester methods of abortion with respect to efficacy, side effects and acceptability and to highlight the need for randomized studies to set guidelines for mid- Trimester abortion methods in terms of safety and acceptance as well as for better analgesic regimens. Expand
Verifying the effectiveness of medical abortion; ultrasound versus hCG testing.
Measuring serum hCG before treatment and at follow-up is more effective than ultrasound to confirm a successful medically induced abortion in early pregnancy. Expand
The effect of the antiprogestin RU 486 on uterine contractility and sensitivity to prostaglandin and oxytocin
The addition of one intramuscular injection of 16‐phenoxy‐PGE2 on the fourth day of treatment with RU 486 (25 mg twice daily) significantly increased the abortifacient effect of the antiprogestin during early pregnancy and the present study suggests that a shorter treatment may be possible. Expand
The effect of various doses of mifepristone on endometrial leukaemia inhibitory factor expression in the midluteal phase--an immunohistochemical study.
It is revealed that early luteal phase treatment as well as intermittent or daily low dose treatment with mifepristone reduces endometrial glandular LIF expression at the expected time of implantation, which further support the contraceptive potential of mifEPristone in low doses. Expand
Effect of post‐coital contraceptive methods on the endometrium and the menstrual cycle
Study objective. To evaluate the effect of treatment with ethinylesteradiol‐levonorgestrel or danazol on ovarian function, gonadotrophin release and endometrial development during the time when aExpand
Contraceptive efficacy of low doses of mifepristone.
A low dose of mifepristone, which does not inhibit ovulation, reduces fertility significantly by affecting the endometrium, however, the contraceptive effect needs to be improved for the drug to compete with other contraceptive methods. Expand
Pharmacokinetics of prostaglandins.
  • M. Bygdeman
  • Medicine
  • Best practice & research. Clinical obstetrics…
  • 1 October 2003
Endocervical administration of PGE(2) might be regarded as a local therapy, while following vaginal administration increased plasma levels of metabolites can generally be found, and the plasma profile varies with the vehicle used. Expand
Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies
This study shows that human fetal mesencephalic tissue pieces survive grafting into nude rats, develop normal vascularization, and express coexistence of TH- and Thy-1-immunoreactivity. Expand