PD-1 and its ligands in tolerance and immunity.
Current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential are discussed and an inhibitory bidirectional interaction between PD-L1 and B7-1 is discovered, revealing new ways the B7:CD28 family regulates T cell activation and tolerance.
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Patterned paper as a platform for inexpensive, low-volume, portable bioassays.
This communication describes a simple method for patterning paper to create well-defined, millimeter-sized channels, comprising hydrophilic paper bounded by hydrophobic polymer, that will become the basis for low-cost, portable, and technically simple multiplexed bioassays.
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Human induced pluripotent stem cells generated from patients with familial dilated cardiomyopathy model cardiovascular disease could provide an important platform to investigate the specific disease mechanisms of DCM as well as other inherited cardiovascular disorders and for screening new drugs for cardiovascular disease.
Interaction of human PD-L1 and B7-1.
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardIAL infarction in humans.
Differential fates of biomolecules delivered to target cells via extracellular vesicles
- M. Kanada, M. Bachmann, C. Contag
- Biology, EngineeringProceedings of the National Academy of Sciences
- 23 February 2015
It is observed that only microvesicles (MVs) can functionally transfer loaded reporter molecules to recipient cells, largely by delivering plasmid DNA, and that exosomes and MVs are structurally and functionally distinct.
Topological and phenomenological classification of bursting oscillations.
Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis
- S. Kulkarni, M. Micci, P. Pasricha
- Biology, MedicineProceedings of the National Academy of Sciences
- 18 April 2017
Significance The demonstration of a robust neurogenesis program in the adult gut and the existence of an enteric neural precursor cell (ENPC) responsible for the same has profound biological and…