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PD-1 and its ligands in tolerance and immunity.
Current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential are discussed and an inhibitory bidirectional interaction between PD-L1 and B7-1 is discovered, revealing new ways the B7:CD28 family regulates T cell activation and tolerance. Expand
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
These findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family. Expand
Patterned paper as a platform for inexpensive, low-volume, portable bioassays.
- Andres W Martinez, S. T. Phillips, M. Butte, G. Whitesides
- Chemistry, Medicine
- Angewandte Chemie
- 12 February 2007
This communication describes a simple method for patterning paper to create well-defined, millimeter-sized channels, comprising hydrophilic paper bounded by hydrophobic polymer, that will become the basis for low-cost, portable, and technically simple multiplexed bioassays. Expand
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
The results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity. Expand
Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
- N. Sun, M. Yazawa, +18 authors Joseph C. Wu
- Biology, Medicine
- Science Translational Medicine
- 18 April 2012
Human induced pluripotent stem cells generated from patients with familial dilated cardiomyopathy model cardiovascular disease could provide an important platform to investigate the specific disease mechanisms of DCM as well as other inherited cardiovascular disorders and for screening new drugs for cardiovascular disease. Expand
Interaction of human PD-L1 and B7-1.
- M. Butte, V. Peña-Cruz, Mi-Jung Kim, G. Freeman, A. Sharpe
- Biology, Medicine
- Molecular immunology
- 1 August 2008
It is shown that human B 7-1 can interact with human PD-L1 with affinity greater than that of B7-1 with CD28, but less than that with CTLA-4 or of PD-l1 with PD-1, suggesting that PD- L1 may play an important and undervalued role on human T cells. Expand
Differential fates of biomolecules delivered to target cells via extracellular vesicles
- M. Kanada, M. Bachmann, +9 authors C. Contag
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 23 February 2015
It is observed that only microvesicles (MVs) can functionally transfer loaded reporter molecules to recipient cells, largely by delivering plasmid DNA, and that exosomes and MVs are structurally and functionally distinct. Expand
Topological and phenomenological classification of bursting oscillations.
- R. Bertram, M. Butte, T. Kiemel, A. Sherman
- Mathematics, Medicine
- Bulletin of mathematical biology
A classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media is described, addressing the issue of how well the bursting can be characterized given the limited amount of information often available in experimental settings. Expand
Topological and phenomenological classification of bursting oscillations
We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of Rinzel… Expand
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardIAL infarction in humans. Expand