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The respiratory consequences of feeding in amphibians and reptiles.
Imaging hypoxia to improve radiotherapy outcome
- M. Horsman, L. S. Mortensen, J. Petersen, M. Busk, J. Overgaard
- MedicineNature Reviews Clinical Oncology
- 1 December 2012
The potential use of imaging to help improve clinical outcome to radiotherapy is critically assessed to identify those patients on an individual basis who have hypoxic tumours and, thus, at the very least should receive some form of hypoxic modifier in conjunction with radiotherapy.
FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial.
Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer.
Findings show that the classifier attained both prognostic and predictive impact, and its pretherapeutic use may provide a method to identify those patients who will benefit from hypoxic modification of radiotherapy.
Respiratory consequences of feeding in the snake Python molorus.
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
- S. Landor, A. Mutvei, C. Sahlgren
- Biology, ChemistryProceedings of the National Academy of Sciences
- 7 November 2011
It is shown that Notch signaling is a key regulator of cellular metabolism and required for metabolic flexibility, and a role for Notch in cellular energy homeostasis is revealed.
Effects of feeding on metabolism, gas transport, and acid-base balance in the bullfrog Rana catesbeiana.
Bullfrogs partly submerged in water were fed meals amounting to approximately (1)/(10) of their body weight, and there was no sign of anaerobic energy production during digestion as plasma and tissue lactate levels remained low and intracellular ATP concentration stayed high.
Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia
- M. Busk, M. Horsman, P. Kristjansen, A. J. van der Kogel, J. Bussink, J. Overgaard
- BiologyInternational journal of cancer
- 15 June 2008
Glycolytic and mitochondrial ATP generation in normoxic and anoxic cell lines was characterized and Glut‐1's value as a hypoxia marker is not severely restricted by aerobic glycolysis, suggesting that multi‐tracer imaging combining FDG and Hypoxia‐specific markers may provide therapeutically relevant information on tumor energetic phenotypes.
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma.
Effects of feeding on arterial blood gases in the American alligator Alligator mississippiensis.
- M. Busk, J. Overgaard, J. Hicks, A. F. Bennett, T. Wang
- BiologyJournal of Experimental Biology
- 15 October 2000
The view that the specific HCO3(-) effect prevents an increased blood oxygen-affinity during digestion in alligators is supported, as the in vitro blood oxygen -affinity was reduced during the post-prandial period, whereas the estimated in vivo blood oxygen,affinity remained virtually constant.