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The respiratory consequences of feeding in amphibians and reptiles.
TLDR
The studies on cardiorespiratory responses to digestion may allow for a further understanding of the physiological and structural constraints that limits the ability of reptiles and amphibians to sustain high metabolic rates. Expand
Imaging hypoxia to improve radiotherapy outcome
TLDR
The potential use of imaging to help improve clinical outcome to radiotherapy is critically assessed to identify those patients on an individual basis who have hypoxic tumours and, thus, at the very least should receive some form of hypoxic modifier in conjunction with radiotherapy. Expand
FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial.
TLDR
The role of FAZA PET/CT imaging as a suitable assay with prognostic potential for detection of hypoxia in HNSCC is emphasized. Expand
Respiratory consequences of feeding in the snake Python molorus.
TLDR
The small changes in plasma [HCO3-] and stable pH show that pythons respond very differently to digestion than alligators where very large alkaline tides have been observed, and it seems worthwhile to describe arterial blood gases during digestion in other species of ectothermic vertebrates. Expand
Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer.
TLDR
Findings show that the classifier attained both prognostic and predictive impact, and its pretherapeutic use may provide a method to identify those patients who will benefit from hypoxic modification of radiotherapy. Expand
Effects of feeding on metabolism, gas transport, and acid-base balance in the bullfrog Rana catesbeiana.
TLDR
Bullfrogs partly submerged in water were fed meals amounting to approximately (1)/(10) of their body weight, and there was no sign of anaerobic energy production during digestion as plasma and tissue lactate levels remained low and intracellular ATP concentration stayed high. Expand
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma.
TLDR
Four of the 5 patients with gut dysmotility had immunoglobulin G antibodies reactive with neurons of the myenteric and submucosal plexuses of jejunum and stomach in an indirect immunofluorescence assay, suggesting that intestinal pseudoobstruction occurring in patients with small-cell carcinoma may have an autoimmune basis. Expand
Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia
TLDR
Glycolytic and mitochondrial ATP generation in normoxic and anoxic cell lines was characterized and Glut‐1's value as a hypoxia marker is not severely restricted by aerobic glycolysis, suggesting that multi‐tracer imaging combining FDG and Hypoxia‐specific markers may provide therapeutically relevant information on tumor energetic phenotypes. Expand
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
TLDR
It is shown that Notch signaling is a key regulator of cellular metabolism and required for metabolic flexibility, and a role for Notch in cellular energy homeostasis is revealed. Expand
Effects of feeding on arterial blood gases in the American alligator Alligator mississippiensis.
TLDR
The view that the specific HCO3(-) effect prevents an increased blood oxygen-affinity during digestion in alligators is supported, as the in vitro blood oxygen -affinity was reduced during the post-prandial period, whereas the estimated in vivo blood oxygen,affinity remained virtually constant. Expand
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