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The Unique C-terminal Tail of the Mitogen-activated Protein Kinase ERK5 Regulates Its Activation and Nuclear Shuttling*
ERK5 is unique among mitogen-activated protein kinases (MAPKs) in that it contains a large C-terminal tail. We addressed the question of how this tail could affect the signaling capacity of ERK5.Expand
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Abl‐kinase‐sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival
It is well established that the mitogen‐activated protein kinase (MAPK) signal is regulated through phosphorylation‐dependent activation by the three‐tiered MAPK cascade. However, our studies on theExpand
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Negative Regulation of HER2 Signaling by the PEST-type Protein-tyrosine Phosphatase BDP1*
Signaling by receptor tyrosine kinases (RTK) mediates a variety of complex cellular functions and in case of deregulation can contribute to pathophysiological processes. A tight and finely tunedExpand
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Phosphotyrosine-specific Phosphatase PTP-SL Regulates the ERK5 Signaling Pathway*
The duration and the magnitude of mitogen-activated protein kinase (MAPK) activation specifies signal identity and thus allows the regulation of diverse cellular functions by the same kinase cascade.Expand
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MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells
ABSTRACT One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provideExpand
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E-box-independent regulation of transcription and differentiation by MYC
MYC proto-oncogene is a key player in cell homeostasis that is commonly deregulated in human carcinogenesis. MYC can either activate or repress target genes by forming a complex with MAX (ref. ). MYCExpand
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MacroH2A in stem cells: a story beyond gene repression.
The importance of epigenetic mechanisms is most clearly illustrated during early development when a totipotent cell goes through multiple cell fate transitions to form the many different cell typesExpand
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PML4 induces differentiation by Myc destabilization
Opposing functions like oncogene and tumor suppressions have been established for c-Myc and promyelocytic leukemia (PML) protein, respectively. Myc is known to inhibit differentiation ofExpand
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Strategies to Overcome Resistance to Targeted Protein Kinase Inhibitors in the Treatment of Cancer
Inhibition of oncogenic protein kinases by small compound inhibitors has proven to be a valuable strategy for the directed and target-specific treatment of an ever-increasing number of cancer types.Expand
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DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression.
Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic basisExpand
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