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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide.Expand
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Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and inExpand
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Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection
Objectives: The characterization of primary HIV infection by the analysis of serial plasma samples from newly infected persons using multiple standard viral assays. Design: A retrospective studyExpand
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Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection
BACKGROUND: A study was designed to estimate relative analytic sensitivity and window‐period (WP) closure and to project incremental yield of newer HBsAg tests, pooled‐sample NAT, and single‐sampleExpand
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Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to beExpand
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The Risk of Transfusion-Transmitted Viral Infections
Background Accurate estimates of the risk of transfusion-transmitted infectious disease are essential for monitoring the safety of the blood supply and evaluating the potential effect of newExpand
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Hepatitis C virus seroconversion among young injection drug users: relationships and risks.
The present study examined reasons for the high incidence of hepatitis C virus (HCV) infection among young injection drug users (IDUs). IDUs <30 years old who tested negative for HCV antibody wereExpand
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Time trends in primary HIV-1 drug resistance among recently infected persons.
CONTEXT Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy. OBJECTIVE To determine trends in prevalence ofExpand
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Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection.
BACKGROUND Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent mostExpand
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New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes.
CONTEXT Differentiating individuals with early human immunodeficiency virus 1 (HIV-1) infection from those infected for longer periods is difficult but important for estimating HIV incidence and forExpand
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