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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide.… Expand
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
- B. Keele, E. Giorgi, +34 authors G. Shaw
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 27 May 2008
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in… Expand
Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection
Objectives: The characterization of primary HIV infection by the analysis of serial plasma samples from newly infected persons using multiple standard viral assays. Design: A retrospective study… Expand
Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection
BACKGROUND: A study was designed to estimate relative analytic sensitivity and window‐period (WP) closure and to project incremental yield of newer HBsAg tests, pooled‐sample NAT, and single‐sample… Expand
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be… Expand
The Risk of Transfusion-Transmitted Viral Infections
Background Accurate estimates of the risk of transfusion-transmitted infectious disease are essential for monitoring the safety of the blood supply and evaluating the potential effect of new… Expand
Hepatitis C virus seroconversion among young injection drug users: relationships and risks.
- J. Hahn, K. Page-Shafer, +7 authors A. Moss
- The Journal of infectious diseases
- 1 December 2002
The present study examined reasons for the high incidence of hepatitis C virus (HCV) infection among young injection drug users (IDUs). IDUs <30 years old who tested negative for HCV antibody were… Expand
Time trends in primary HIV-1 drug resistance among recently infected persons.
CONTEXT Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy. OBJECTIVE To determine trends in prevalence of… Expand
Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection.
BACKGROUND Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most… Expand
New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes.
CONTEXT Differentiating individuals with early human immunodeficiency virus 1 (HIV-1) infection from those infected for longer periods is difficult but important for estimating HIV incidence and for… Expand