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Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
TLDR
It is shown that more powerful inputs are strongly favoured competitors during synapse elimination, and a genetic method is used to selectively inhibit neurotransmission from one of two inputs to a single target cell. Expand
Effects of long‐term conduction block on membrane properties of reinnervated and normally innervated rat skeletal muscle.
TLDR
It is concluded that muscle evoked activity is the physiological regulator of extrajunctional membrane properties and chemical factors from the nerve do not appear to participate in this regulation. Expand
Paralysis of rat skeletal muscle equally affects contractile properties as does permanent denervation
TLDR
The results indicate the fundamental role of activity as a regulatory signal for muscle contractile properties, while they do not support the notion of a participation of chemical, activity-independent factors in this regulation. Expand
Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum
TLDR
It is shown that normal electrical activity of the postsynaptic cell is required for it to attain a mature innervation pattern and that normal redistribution of climbing fiber synapses from PC somata to proximal dendrites was also blunted in transgenics. Expand
Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis
TLDR
It is shown that CFTR-associated activity can be evaluated in 5 ml of peripheral blood and devise an index potentially applicable for diagnostic purposes and both basic and translational research. Expand
Perinatal switch from synchronous to asynchronous activity of motoneurons: Link with synapse elimination
TLDR
In vivo rat motoneuronal firing during late embryonic and early neonatal life, when synapse elimination occurs in muscle, supports a developmental model in which synchronous activity first favors polyneuronal innervation, whereas an asynchronous one subsequently promotes synapses elimination. Expand
In vivo multiphoton nanosurgery on cortical neurons.
TLDR
The spatial precision of this method is demonstrated by ablating individual dendritic spines, while sparing the adjacent spines and the structural integrity of the dendrite, as a promising tool for neurobiology and neuropharmacology research. Expand
Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound
TLDR
Chronic oral administration of peptide 021 (P021), a small peptidergic neurotrophic compound derived from the ciliary neurotrophic factor, significantly reduced the age-dependent decline in learning and memory in 22 to 24-month-old Fisher rats and restored synaptic deficits both in the cortex and the hippocampus. Expand
Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease
TLDR
The intranasal route of administration of EVs, derived from cytokine‐preconditioned MSCs, was able to induce immunomodulatory and neuroprotective effects in AD, and MSC‐EVs polarized in vitro murine primary microglia toward an anti‐inflammatory phenotype suggesting that the neuroProtective effects observed in transgenic mice could result from a positive modulation of the inflammatory status. Expand
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
TLDR
It is shown that the Rho-GTPase family member Rac1 levels decreased in the frontal cortex of AD patients compared to non-demented controls and the intriguing possibility of a dual role of Rac1 according to the different stages of the pathology is suggested. Expand
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