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Ventral Tegmental Area BDNF Induces an Opiate-Dependent–Like Reward State in Naïve Rats
It is found that a single infusion of BDNF into the VTA promotes a shift from an opiate-naïve, dopamine-independent to a dopamine-dependent opiate reward system, identical to that seen when an opiates-naive rat becomes dependent and withdrawn. Expand
The asymmetric segregation of damaged proteins is stem cell–type dependent
Asymmetric segregation of damaged proteins is detectable in three different adult tissue stem cells in Drosophila melanogaster but does not always favor segregation away from the stem cell.
Establishment of long term cultures of neural stem cells from adult sea bass, Dicentrarchus labrax.
Sea bass brain tissues were dissected, dispersed and cultured in Leibovitz's L-15 media supplemented with 10% fetal bovine serum indicating their viability and suitability as convenient models for neurophysiological or neurotoxicological studies. Expand
Cytotoxicity evaluation of silica nanoparticles using fish cell lines
Fish cell lines could be valuable for screening emerging contaminants in aquatic environments including NPs through rapid high-throughput cytotoxicity bioassays, in overall agreement with similar human and mouse cell studies reported to date. Expand
BDNF Signaling in the VTA Links the Drug-Dependent State to Drug Withdrawal Aversions
Chronic opiate administration activates BDNF-related neuronal plasticity in the VTA that is necessary for both the establishment of an opiate-dependent state and aversive withdrawal motivation, highlighting the importance of a bivalent, plastic mechanism that drives the negative reinforcement underlying addiction. Expand
Infusion of brain‐derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation
It is suggested that intra‐VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug‐naive, non‐deprived state to a drug- Deprived state. Expand
Misidentification of OLGA-PH-J/92, believed to be the only crustacean cell line
Results unequivocally indicate that the OLGA-PH-J/92 cell line is not derived from the crayfish O. limosus, and the search for an immortal crustacean cell line continues. Expand
The aggregation and inheritance of damaged proteins determines cell fate during mitosis
It is demonstrated that asymmetric division resulting from a cell containing a single inclusion body produces sister cells with different fates, and it is suggested that this is a result of inclusion body-induced proteasome impairment. Expand
Asymmetric Division of Damaged Proteins in Proliferating Cells
It is suggested that functional lifespan, and not cell type, determines the cell that receives the majority of damaged proteins during division and that both the larval neuroblast and female germline stem cell are vulnerable to this fate. Expand