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A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
A new cell population that expresses the transcription factors Pax3 and Pax7 but no skeletal-muscle-specific markers constitutes a source of myogenic cells of prime importance for skeletal muscle formation, a finding also of potential value in the context of cell therapy for muscle disease.
Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells
Two novel markers of quiescent satellite cells are described: CD34, an established marker of hematopoietic stem cells, and Myf5, the earliest marker of myogenic commitment, which are concluded to define quyingcent, committed precursors and speculate that the CD34−ve, Myf 5−ve minority may be involved in maintaining the lineage-committed majority.
Building the mammalian heart from two sources of myocardial cells
The recent identification of a second source of myocardial cells that make an important contribution to the cardiac chambers has modified the classical view of heart formation.
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
Manipulation of the dominant-negative forms of these factors in satellite cell cultures demonstrates that Pax3 cannot replace the antiapoptotic function of Pax7, and underline the importance of cell survival in controlling the stem cell populations of adult tissues.
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
A Pax3GFP/+ mouse line is used to directly isolate (Pax3)(green fluorescent protein)–expressing muscle satellite cells, by flow cytometry from adult skeletal muscles, as a homogeneous population of small, nongranular, Pax7+, CD34+, CD45–, Sca1– cells.
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
It is shown that skeletal muscle is present in the new Myf5:Myod double-null mice only when Mrf4 expression is not compromised, which contradicts the widely held view that myogenic identity is conferred solely by Myf 5 and Myod, and identifies Mrf 4 as a determination gene.
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo.
Both the appearance and disappearance of myf-5 follow the anteroposterior gradient of somite formation and maturation in the embryo, consistent with a role in the early events of myogenic differentiation.
Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis
The pattern of expression of MyoDl and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro indicates that they may have different functions in different types of muscle during development.