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A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior
TLDR
An electroencephalographic-derived index of human consciousness that reflects the information content of the brain’s response to a magnetic stimulus is defined, and appears to be a robust measure that distinguishes conscious from unconscious states well enough to be used on an individual basis, a prerequisite for deployment in the clinic. Expand
Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness
TLDR
It is suggested that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. Expand
Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
TLDR
It is shown that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment, as well as in healthy controls and locked-in syndrome patients. Expand
From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness
TLDR
An improved assessment of brain function in coma and related states is not only changing nosology and medical care but also offers a better-documented diagnosis and prognosis and helps to further identify the neural correlates of human consciousness. Expand
Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients
TLDR
Measurements of effective connectivity by means of transcranial magnetic stimulation combined with electroencephalography can be performed at the bedside while by-passing subcortical afferent and efferent pathways, and without requiring active participation of subjects or language comprehension; hence, they offer an effective way to detect and track recovery of consciousness in brain-injured patients who are unable to exchange information with the external environment. Expand
Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State
TLDR
It is found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices, which emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception. Expand
Propofol anesthesia and sleep: a high-density EEG study.
TLDR
Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity. Expand
Complexity of Multi-Dimensional Spontaneous EEG Decreases during Propofol Induced General Anaesthesia
TLDR
There is a robustly measurable decrease in the complexity of spontaneous EEG during general anaesthesia, and three distinct measures are considered which capture distinct ‘flavours’ of complexity. Expand
Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study
TLDR
Cerebral PET could be used to complement bedside examinations and predict long-term recovery of patients with unresponsive wakefulness syndrome and active fMRI might also be useful for differential diagnosis, but seems to be less accurate. Expand
Brain functional integration decreases during propofol-induced loss of consciousness
TLDR
The findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol, and stress the important role played by parietal and frontal areas in the generation of consciousness. Expand
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