A receptor-mediated pathway for cholesterol homeostasis.
- M. Brown, J. Goldstein
- BiologyScience
- 4 April 1986
The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
- J. Ye, R. B. Rawson, J. Goldstein
- BiologyMolecules and Cells
- 1 December 2000
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
- J. Repa, G. Liang, D. Mangelsdorf
- BiologyGenes & Development
- 2000
A novel LXR target is described, the sterol regulatory element-binding protein-1c gene (SREBP-1C), which encodes a membrane-bound transcription factor of the basic helix-loop-helix-leucine zipper family and reveals a unique regulatory interplay between cholesterol and fatty acid metabolism.
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
- M. Brown, J. Goldstein
- BiologyProceedings of the National Academy of Sciences…
- 28 September 1999
These regulated proteolytic cleavage reactions are ultimately responsible for controlling the level of cholesterol in membranes, cells, and blood.
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.
- J. Goldstein, Y. Ho, S. Basu, M. Brown
- BiologyProceedings of the National Academy of Sciences…
- 1979
It is hypothesized that this macrophage uptake mechanism may mediate the degradation of denatured LDL in the body and thus serve as a "backup" mechanism for the previously described receptor-mediated degradation of native LDL that occurs in parenchymal cells.
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
- S. Ishibashi, M. Brown, J. Goldstein, R. Gerard, R. Hammer, J. Herz
- Biology, MedicineJournal of Clinical Investigation
- 1 August 1993
It is concluded that the LDL receptor is responsible in part for the low levels of VLDL, IDL, and LDL in wild-type mice and that adenovirus-encoded LDL receptors can acutely reverse the hypercholesterolemic effects of LDL receptor deficiency.
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.
- J. Goldstein, S. Basu, M. Brown
- Biology, MedicineMethods in Enzymology
- 1983
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
- H. Shimano, J. Horton, I. Shimomura, R. Hammer, M. Brown, J. Goldstein
- BiologyJournal of Clinical Investigation
- 1 March 1997
SRE BP-1a is the most active form of SREBP-1 and that SREbp-1c may be produced when cells require a lower rate of transcription of genes regulating cholesterol and fatty acid metabolism.
Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.
- M. Brown, J. Goldstein
- Biology, ChemistryAnnual Review of Biochemistry
- 1983
The cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques and the Foam Cell in Familial Hypercholesterolemia are studied.
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.
- H. Hobbs, D. Russell, M. Brown, J. Goldstein
- BiologyAnnual Review of Genetics
- 22 July 1990
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