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Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior
  • M. Bronson
  • Medicine
    Pharmacology Biochemistry and Behavior
  • 1 June 1994
The results support those of others who found that high doses of CDAP were required to produce acute physical dependence and that chronic administration of bretazenil does not result in physical dependence.
Effect of once weekly treatment with 3,4-methylenedioxymethamphetamine on schedule-controlled behavior in rats.
It appears that even weekly dosing with a small amount of MDMA can have long-lasting effects that are manifested in both operant and spontaneous behavior and that may be mediated by a conditioning mechanism.
Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin
It was concluded that chronic impairment of dopaminergic innervation to the nucleus accumbens results in an enhanced response to DALA injected directly into the nucleus Accumbens.
Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine (MDMA) derivatives.
The results of these experiments suggest that structurally related compounds share some stimulus properties with MDMA and may therefore share abuse liability.
Structure-activity relationships of BDB and its monomethyl and dimethyl derivatives
The primary amine, BDB, produced effects that are commonly seen in the chicken after administration of both hallucinogens and psychomotor stimulants (i.e., distress vocalization, tremor, and wing extension), and this effect is typical of d-amphetamine but has not been reported for hallucinogenic effects.
Serotonin involvement in the discriminative stimulus effects of κ opioids in pigeons
The purpose of the present study was to examine the role of serotonin (5HT) in the discriminative stimulus effects ofκ opioids. Pigeons were trained to discriminate 5.6 mg/kg of theκ opioid, U50,488,
Serotonin involvement in the discriminative stimulus effects of kappa opioids in pigeons.
The results suggest that serotonin release is an important component in the discriminative stimulus effects produced by kappa opioids; however, the effects of DOI and mCPP alone suggest that activation of post-synaptic 5HT receptors is not sufficient to produce the full spectrum of kappa opioid discriminatives stimulus effects.
Effects of designer drugs on the chicken embryo and 1-day-old chicken
With the exception of MDM1EA, all of the drugs produced effects such as distress vocalization, wing extension, tremor, flat body posture, bursting forward movements, loss of righting reflex, and convulsant-like kicking.
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos
Isobutylmethylxanthine (IBMX), a compound that produces quasi-opioid withdrawal, was injected directly into the embryo, resulting in a significant increase in motility, and Pretreatment with the irreversible mu antagonist, beta-funaltrexamine (B-FNA), blocked the decrease inMotility seen after Meth and also prevented the overshoot in Motility when Nx was given 1 hour post-Meth.