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Effect of fungal metabolite peramine and analogs on feeding and development of argentine stem weevil (Listronotus bonariensis)
A number of simple peramine analogues showed feeding-deterrent activity against adult weevils, indicating the importance of the pyrrolopyrazine ring system of peramine in determining feeding-Deterrent Activity.
Synthesis of isotopically labelled thiol volatiles and cysteine conjugates for quantification of Sauvignon Blanc wine
The thiols 4-mercapto-4-methylpentan-2-ol (4MMPOH), 3-mercaptohexan-1-ol (3MH), and 3-mercaptohexyl acetate (3MHA), which contribute to the aroma profile of Sauvignon Blanc, as well as other
Identification of key residues involved in adrenomedullin binding to the AM1 receptor
Adrenomedullin plays a significant role in angiogenesis and its antagonist fragment AM22–52 can inhibit blood vessel and tumour growth.
Plant antimicrobial peptides snakin-1 and snakin-2: chemical synthesis and insights into the disulfide connectivity.
It is demonstrated that synthetic snakin-2 possesses full antifungal activity and displayed similar chromatographic behaviour to natural Snakin-1 and -2.
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes.
Molecules derived from the extremes of life.
This review highlights novel molecules isolated from microorganisms that either tolerate or favour extreme growth conditions.
Pyranonaphthoquinone antibiotics--isolation, structure and biological activity.
An overview of monomeric, dimeric and carbohydrate derived pyranonaphthoquinones will be presented which includes several new compounds appearing in the literature between 1989 and the present time.
Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11
A review of the range of pharmacological and molecular tools available for the study of the role of Gαq/11 in GPCR signaling and how they could potentially represent a novel therapeutic target is explored.
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors.
This study more clearly defines the biological effects of MLA analogues at nA ChRs and demonstrates that these analogues are not selective ligands for the alpha7 nAChR subtype.
NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke
In vitro, NNZ-2566 significantly attenuates apoptotic cell death in primary striatal cultures, suggesting attenuation of apoptosis is one mechanism of action underlying its neuroprotective effects.