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Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte
ABSTRACT Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor implicated in adipocyte differentiation and insulin sensitivity. We investigated whether PPARγ expression isExpand
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Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages.
OBJECTIVES Adipose tissue from patients with HIV-related lipodystrophy presents a state of chronic inflammation. Altered expression of cytokines/adipokines and macrophage infiltration could beExpand
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The X-Ray, Optical, and Infrared Counterpart to GRB 980703
We report on X-ray, optical, and infrared follow-up observations of GRB 980703. We detect a previously unknown X-ray source in the GRB error box; assuming a power-law decline, we find for its decayExpand
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Cloning, expression, and initial characterization of a novel cytokine-like gene family.
We report the identification and characterization of a novel cytokine-like gene family using structure-based methods to search for novel four-helix-bundle cytokines in genomics databases. There areExpand
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Propagation and amplification of tsunamis at coastal boundaries
WHEN tsunamis hit a coastal area, they often cause substantial damage and loss of life at locations otherwise well protected from normal (even severe) wind-generated waves. An example of such aExpand
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Stimulation of autologous proliferative and cytotoxic T-cell responses by "leukemic dendritic cells" derived from blast cells in acute myeloid leukemia.
Effective presentation of tumor antigens is fundamental to strategies aimed at enrolling the immune system in eradication of residual disease after conventional treatments. Myeloid malignanciesExpand
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Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes.
Overexpression of the adipocyte differentiation and determination factor-1 (ADD-1) or sterol regulatory element binding protein-1 (SREBP-1) induces the expression of numerous genes involved in lipidExpand
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Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis.
Adipocyte differentiation is driven by the expression and activation of three transcription factor families: the differentially expressed CAAT/enhancer binding proteins (C/EBPs) alpha, beta, andExpand
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Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling.
A strategy is presented to predict interindividual variation in drug plasma levels in vivo by the use of physiologically based pharmacokinetic modeling and human in vitro metabolic parameters,Expand
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Lysosomal enzyme activation by steroid hormones in vivo.
  • M. Briggs
  • Biology, Medicine
  • Journal of steroid biochemistry
  • 1 July 1973
Abstract A series of 23 hormonal steroids and stilbestrol were examined for effects on β-glucuronidase activity of autolysed lysosome preparations from rat preputial glands. Compounds wereExpand
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