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Cyclodextrins as pharmaceutical solubilizers.
Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization.
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.
Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?
Methods and excipients associated with the development of supersaturating drug delivery systems are assessed and the future directions and factors likely to contribute to or detract from optimal dosage form selection are assessed.
Cyclodextrin-based pharmaceutics: past, present and future
Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
Pharmaceutical applications of cyclodextrins: basic science and product development
This short review is intended to provide both some basic science information as well as data on the ability to develop drugs in cyclodextrin‐containing formulations.
Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7.
- J. Peeters, Peter Neeskens, J. Tollenaere, P. van Remoortere, M. Brewster
- Chemistry, BiologyJournal of pharmaceutical sciences
- 1 June 2002
Molecular mechanics suggest 1:3 complex formation for the neutral species, indicating that possible interaction sites may include (in order of binding) triazole > 1,4-diaminophenyl > 2-butyl approximate, equals piperazine.
In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including…
Cyclodextrins as functional excipients: methods to enhance complexation efficiency.
A brief review assesses tools and materials suggested for increasing the CE for pharmaceutically useful cyclodextrins and drugs.
Preclinical and Clinical Studies
- M. Brewster, G. Verreck, Jan Bevernage, J. Brouwers, G. Mooter, P. Augustijns
- 25 February 2015
Preclinical and clinical models for assessing solid dispersion fitness will contribute to the drug development process by helping to assess the potential utility of amorphous solid dispersions and itraconazole supersaturation.