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Microarray Analyses of Peripheral Blood Cells Identifies Unique Gene Expression Signature in Psoriatic Arthritis
TLDR
PBC gene expression profiling identified a gene expression signature that differentiated PsA from RA, andPsA from controls, and several novel genes were differentially expressed and may prove to be diagnostic biomarkers or serve as new targets for the development of therapies. Expand
CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis.
TLDR
It is suggested that the CXCL10/CXCR3 axis is a potential new target for therapies aimed at reducing FLS invasion and its associated joint damage and pannus invasion and destruction in RA. Expand
Whole-Genome Sequences of DA and F344 Rats with Different Susceptibilities to Arthritis, Autoimmunity, Inflammation and Cancer
TLDR
Genetic differences between DA, F344, and BN, including high-impact SNPs and short insertions and deletions affecting >2500 genes, are likely to account for most of the phenotypic variation between these strains. Expand
A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.
TLDR
It is shown how one obstacle to progress, the fine-mapping of quantitative trait loci (QTL), can be overcome by using an outbred population of rats to map a locus contributing to variation in a fear-related measure to a region on chromosome 5 containing nine genes. Expand
The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-α and Nitric Oxide1
TLDR
This is the first time that non-MHC autoimmune arthritis loci are found to regulate three central components of the innate immune response implicated in disease pathogenesis, namely neutrophil migration into an inflammatory site, as well as exudate levels of TNF-α and NO. Expand
The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage.
TLDR
This study determined that Cia10 harbors a major autoimmune arthritis-regulatory gene that regulates clinical disease severity, histologic damage, and the levels of at least two central proinflammatory cytokines in rats with pristane-induced arthritis. Expand
Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice
TLDR
In conclusion, rhMFG-E8 ameliorates DSS- and TNBS-induced colitis, suggesting that it has the potential to become a novel therapeutic agent for IBD. Expand
Thermal signature analysis as a novel method for evaluating inflammatory arthritis activity
TLDR
The technique was highly sensitive and could measure directly two cardinal signs of inflammation in an area (ankle) that is less than half the size of a human interphalangeal joint, suggesting a potential use in drug trials or clinical practice. Expand
Buprenorphine Markedly Elevates a Panel of Surrogate Markers in a Murine Model of Sepsis
TLDR
Repeated administration of buprenorphine is strongly recommended not to repetitively administer to eliminate its potential complication to animal sepsis models, which may adversely jeopardize the ability to use the CLP model to reliably simulate human sepsi, and to understand the complex mechanism underlying the pathogenesis of lethal sepsIS. Expand
Genetic Regulation of T Regulatory, CD4, and CD8 Cell Numbers by the Arthritis Severity Loci Cia5a, Cia5d, and the MHC/Cia1 in the Rat
TLDR
This is the first identification of arthritis severity QTL regulating numbers of CD4+CD 45RCl° (Cia5a) and CD8+CD45RCloCD25+ (CIA5d) Treg cells. Expand
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