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Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7.
TLDR
The results strongly suggest that the two kalikreins are involved in desquamation, a model that could be regulated by a precisely controlled protease-protease inhibitor balance. Expand
A proteolytic cascade of kallikreins in the stratum corneum.
TLDR
It is concluded that the enzymes studied may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance. Expand
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction.
TLDR
These results identify KLK5, a key actor of the desquamation process, as the major target of LEKTI, and disclose a new mechanism of skin homeostasis by which the epidermal pH gradient allows precisely regulated KLK 5 activity and corneodesmosomal cleavage in the most superficial layers of the stratum corneum. Expand
Purification, Molecular Cloning, and Expression of a Human Stratum Corneum Trypsin-like Serine Protease with Possible Function in Desquamation*
TLDR
High expression of the new enzyme in the skin and low expression in brain, placenta, and kidney were shown and the function of this new protease, tentatively named stratum corneum tryptic enzyme, may be related to stratum Corneum turnover and desquamation in the epidermis. Expand
Kallikrein-related peptidases
TLDR
A review on kallikrein-related peptidases, their evolution, their role in skin homeostasis and semen liquefaction, and their utility as cancer biomarkers is reviewed. Expand
Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.
TLDR
This study demonstrated that hK5 and hK7, or more specifically, the short KLK 5 and long KLK7 transcripts, may be useful as tumor markers for epithelial-derived serous carcinomas, but additional clinical studies assessing serum levels of these putative biomarkers are required to confirm their usefulness in the diagnosis and/or monitoring of these tumors. Expand
Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.
TLDR
In vitro results suggest that KLKs may take part in PAR2 activation in the epidermis and thereby inPAR2-mediated inflammatory responses, including epidermal barrier repair and pruritus, and could also show the coexpression of KLK14 and PAR2 receptor in inflammatory skin disorders. Expand
hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6
TLDR
This data indicates that suppression of the activity of SPINK5, the gene encoding the human 15‐domain serine proteinase inhibitor LEKTI, in mice with atopic dermatitis and Netherton syndrome is aapse is aogene, and the biochemical mechanisms underlying this phenomenon are unknown. Expand
Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome.
TLDR
Mechanistic basis for phenotypic variations in Netherton syndrome is provided, and compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack are described. Expand
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
TLDR
Results from expression analyses indicate that stratum corneum tryptic enzyme is as skin specific as stratum Corneum chymotryptic enzyme, and the activity of both enzymes over a broad range of pH-values suggest some possible ways by which the desquamation may be regulated. Expand
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