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Safety and tolerability of once-daily mometasone furoate aqueous nasal spray in children.
Sensitive and reproducible assessments of hypothalamic-pituitary-adrenal (HPA) axis function were used to assess the systemic exposure and tolerability of mometasone furoate aqueous nasal spray… Expand
Pharmacology of bepridil.
- A. Gill, S. Flaim, B. Damiano, S. P. Sit, M. Brannan
- The American journal of cardiology
- 9 April 1992
Bepridil is an antianginal agent with multiple therapeutic actions. It decreases calcium influx through potential-dependent and receptor-operated sarcolemmic calcium channels and acts intracellularly… Expand
Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations
- M. Brannan, P. Reidenberg, +4 authors M. Affrime
- Clinical pharmacology and therapeutics
- 1 September 1995
To evaluate the effects of coadministration of loratadine and erythromycin on the pharmacokinetics and electrocardiographic repolarization (QTc) pharmacodynamics of loratadine and its metabolite… Expand
AMPK activation with AICAR provokes an acute fall in plasma [K+].
- D. Zheng, Anjana Perianayagam, +8 authors A. McDonough
- Chemistry, Medicine
- American journal of physiology. Cell physiology
AMP-activated protein kinase (AMPK), activated by an increase in intracellular AMP-to-ATP ratio, stimulates pathways that can restore ATP levels. We tested the hypothesis that AMPK activation… Expand
Biodistribution of paclitaxel and poly(l-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor
- Chun Li, R. Newman, +7 authors S. Wallace
- Medicine, Chemistry
- Cancer Chemotherapy and Pharmacology
Purpose: Poly(l-glutamic acid)-paclitaxel (PG-TXL) is a water-soluble paclitaxel (TXL) conjugate made by conjugating TXL to poly(l-glutamic acid) via ester bonds. In preclinical studies, PG-TXL has… Expand
Lack of hypothalamic-pituitary-adrenal axis suppression with once-daily or twice-daily beclomethasone dipropionate aqueous nasal spray administered to patients with allergic rhinitis.
The potential for a newly developed, double-strength (0.084%) beclomethasone dipropionate (BDP) aqueous (AQ) nasal suspension to produce effects associated with exposure to systemic corticosteroids… Expand
62 Lack of systemic activity with intranasal mometasone furoate
Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.
- S. Flaim, M. Brannan, S. C. Swigart, M. Gleason, L. D. Muschek
- Proceedings of the National Academy of Sciences…
- 1 February 1985
This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide… Expand
Effects of bepridil hydrochloride on calcium-induced responses in guinea pig Langendorff heart.
A spontaneously beating guinea pig Langendorff heart preparation was used to evaluate and compare the effects of bepridil hydrochloride (BP) and other Ca blockers. Cardiac contractile force was… Expand
Endoscopic prognosis in gastric cancer.
- J. Shabot, G. Roark, M. Brannan, M. Patterson
- Journal of clinical gastroenterology
- 1 February 1983
Sixty-eight patients with gastric adenocarcinoma underwent upper gastrointestinal endoscopy from 1968 to 1975. Tumors were divided into two categories according to their gross characteristics at… Expand