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Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion.
The aim of this study was to develop a novel predictive medium-throughput screening method for drug permeability, with use of a tight barrier of liposomes on a filter support. To our knowledge no oneExpand
In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives.
The application of in vitro models in drug permeability studies represents a useful screening tool for assessing the biopharmaceutical appropriateness of new chemical entities (NCEs). Expand
Protein O‐mannosylation is crucial for cell wall integrity, septation and viability in fission yeast
Protein O‐mannosyltransferases (PMTs) initiate the assembly of O‐mannosyl glycans, which are of fundamental importance in eukaryotes. The PMT family, which is classified into PMT1, PMT2 and PMT4Expand
Drug permeability across a phospholipid vesicle-based barrier 2. Characterization of barrier structure, storage stability and stability towards pH changes.
Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize theExpand
In‐vitro permeability of poorly water soluble drugs in the phospholipid vesicle‐based permeation assay: the influence of nonionic surfactants
Objectives  The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle‐based permeation assay (PVPA), which excludes other thanExpand
Liposomes as drug carriers: a technological approach.
  • M. Brandl
  • Medicine
  • Biotechnology annual review
  • 2001
Liposome researchers have created a hugh variety of liposomal drug carriers in the past thirty years mainly by small-scale laboratory techniques using more or less well defined raw materials. Only aExpand
Drug permeability across a phospholipid vesicle-based barrier 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug permeability.
In this study the integrity of the recently developed phospholipid vesicle-based permeability barrier in the presence of a variety of co-solvents and tensides has been investigated. Also included areExpand
Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: true supersaturation vs. apparent solubility enhancement.
Amorphous solid dispersions (ASDs) represent a promising formulation approach for poorly soluble drugs. We explored the formulation-related impact of ASDs on permeation rate, apparent solubility andExpand
Liposome Preparation by a New High Pressure Homogenizer Gaulin Micron Lab 40
AbstractHigh pressure expansion of lipid dispersions with a lab-scale homogenizer (Gaulin Micron LAB 4 0) was tested to produce forced lecithin hydration and subsequent liposome formation. AExpand
5-Fluorouracil in vesicular phospholipid gels for anticancer treatment: entrapment and release properties.
Vesicular phospholipid gels (VPG), i.e. highly concentrated liposomal dispersions, are suitable for entrapping substances such as anticancer drugs with particular high encapsulation efficienciesExpand