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Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion.
The aim of this study was to develop a novel predictive medium-throughput screening method for drug permeability, with use of a tight barrier of liposomes on a filter support. To our knowledge no oneExpand
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In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives.
The application of in vitro models in drug permeability studies represents a useful screening tool for assessing the biopharmaceutical appropriateness of new chemical entities (NCEs). Of note, thereExpand
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Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.
Protein O-mannosyltransferases (PMTs) initiate the assembly of O-mannosyl glycans, which are of fundamental importance in eukaryotes. The PMT family, which is classified into PMT1, PMT2 and PMT4Expand
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Drug permeability across a phospholipid vesicle-based barrier 2. Characterization of barrier structure, storage stability and stability towards pH changes.
Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize theExpand
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In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay: the influence of nonionic surfactants.
OBJECTIVES The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle-based permeation assay (PVPA), which excludes other thanExpand
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Liposomes as drug carriers: a technological approach.
  • M. Brandl
  • Medicine
  • Biotechnology annual review
  • 2001
Liposome researchers have created a hugh variety of liposomal drug carriers in the past thirty years mainly by small-scale laboratory techniques using more or less well defined raw materials. Only aExpand
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C-H...pi-interactions in proteins.
A non-redundant set of 1154 protein structures from the Protein Data Bank was examined with respect to close interactions between C-H-donor and pi-acceptor groups. A total of 31,087 interactions wereExpand
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Drug permeability across a phospholipid vesicle-based barrier 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug permeability.
In this study the integrity of the recently developed phospholipid vesicle-based permeability barrier in the presence of a variety of co-solvents and tensides has been investigated. Also included areExpand
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Preparation and characterization of semi-solid phospholipid dispersions and dilutions thereof
Highly concentrated, viscous to semi-solid phospholipid dispersions with phosphatidylcholine (PC) contents up to 600 mg/g or 780 mM were obtained by high-pressure homogenization. Dilution of theseExpand
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Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".
The large number of drug candidates with poor dissolution characteristics seen in the past decade, has fostered interest in so-called "enabling formulations", i.e., formulations which shall make suchExpand
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