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Complement Factor H Polymorphism in Age-Related Macular Degeneration
TLDR
A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Complement factor H polymorphism in age-related macular degeneration.
TLDR
A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.
TLDR
It is concluded that in patients with acute spinal-cord injury, treatment with methylprednisolone in the dose used in this study improves neurologic recovery when the medication is given in the first eight hours.
International Standards for Neurological and Functional Classification of Spinal Cord Injury
TLDR
International Standards for Neurological and Functional Classification of Spinal Cord Injury are published and will be used for clinical practice.
Renal impairment and outcomes in heart failure: systematic review and meta-analysis.
TLDR
Renal impairment is common among HF patients and confers excess mortality, and Renal function should be considered in risk stratification and evaluation of therapeutic strategies for HF patients.
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury
TLDR
Patients who received the 48-hour methylprednisolone regimen and who started treatment at 3 to 8 hours were more likely to improve 1 full neurologic grade and show improved motor recovery at 6 weeks and 6 months after injury.
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
TLDR
Treatment with the study dose of methylprednisolone is indicated for acute spinal cord trauma, but only if it can be started within 8 hours of injury.
Steroids for acute spinal cord injury.
  • M. Bracken
  • Medicine
    The Cochrane database of systematic reviews
  • 18 January 2012
TLDR
High-dose methylprednisolone steroid therapy is the only pharmacologic therapy shown to have efficacy in a phase three randomized trial when administered within eight hours of injury and has been shown to improve neurologic outcome up to one year post-injury.
The Second National Acute Spinal Cord Injury Study.
TLDR
The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.
How to increase value and reduce waste when research priorities are set
TLDR
This report discusses how avoidable waste can be considered when research priorities are set and recommends ways to improve the yield from basic research, and the transparency of processes by which funders prioritise important uncertainties should be increased.
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