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The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
OptiPrep density gradient centrifugation outperforms ultracentrifugation and ExoQuick and Total Exosome Isolation precipitation in terms of purity, and the purest exosome fractions reveal a unique mRNA profile enriched for translation, ribosome, mitochondrion and nuclear lumen function.
Stromal myofibroblasts are drivers of invasive cancer growth
Fibrosis is a major side effect of radiotherapy, and the question how the main methods of cancer management, including chemotherapy, hormonotherapy and surgery affect myofibroblasts and by inference the surrogate endpoints invasion and metastasis is addressed.
N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling.
  • L. Derycke, M. Bracke
  • Biology, Medicine
    The International journal of developmental…
  • 1 September 2004
N-cadherin can have multiple functions: promoting adhesion or induction of migration dependent on the cellular context, which in some cancers, like osteosarcoma, may behave as a tumour suppressor.
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.
Identification of the factors that initiate, modulate and effectuate EMT signatures and their underlying upstream oncogenic pathways should provide the basis of more efficient strategies to fight cancer progression as well as genetic and epigenetic forms of drug resistance.
Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac
In vitro results point to a new putative proinvasive signal for colon cancer cells provided by myofibroblasts in the tumor stroma.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Rab27B regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.
E‐cadherin/catenin/cytoskeleton complex: A regulator of cancer invasion
Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.
Nutlin-3 activates the p53 pathway and suppresses tumor growth and reduction in the extent of metastatic disease in this model system of chemoresistant neuroblastoma, provided that wild-type p53 is present.
Frondoside A Suppressive Effects on Lung Cancer Survival, Tumor Growth, Angiogenesis, Invasion, and Metastasis
Frondoside A is identified as a promising novel therapeutic agent for lung cancer and enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin.
TRIP6, a novel molecular partner of the MAGI‐1 scaffolding molecule, promotes invasiveness
TRIP6 overexpression in colon tumors suggest its critical role in cancer progression, and competing peptides corresponding to TRIP6 or β‐catenin C terminus restored invasive properties in MDCKts‐src TRIP 6Stop473 cells, highlighting the requirement of PDZ scaffolds in junctional complexes activity.