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A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution
We report a high-quality chromosome-scale assembly and analysis of the carrot (Daucus carota) genome, the first sequenced genome to include a comparative evolutionary analysis among members of theExpand
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The genomic landscape of tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse and debilitating clinical symptoms.Expand
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Draft Assembly of Elite Inbred Line PH207 Provides Insights into Genomic and Transcriptome Diversity in Maize[OPEN]
Comparative analyses of the maize reference B73 genome assembly and the newly assembled PH207 genome and their transcriptomes provide insights into variation between heterotic groups of elite maize.Expand
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Subgenome Dominance in an Interspecific Hybrid, Synthetic Allopolyploid, and a 140-Year-Old Naturally Established Neo-Allopolyploid Monkeyflower[OPEN]
Subgenome differences in levels of transposon methylation mirror increases in subgenome-specific expression bias observed over generations following hybridization and allopolyploidization in Mimulus.Expand
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Subgenome dominance in an interspecific hybrid, synthetic allopolyploid, and a 140 year old naturally established neo-allopolyploid monkeyflower
The importance and applications of polyploidy have long been recognized, from shaping the evolutionary success of flowering plants to improving agricultural productivity. Recent studies have shownExpand
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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans
Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1Expand
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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.
There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the continued activity ofExpand
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RNA-Seq Transcriptome Profiling of Upland Cotton (Gossypium hirsutum L.) Root Tissue under Water-Deficit Stress
An RNA-Seq experiment was performed using field grown well-watered and naturally rain fed cotton plants to identify differentially expressed transcripts under water-deficit stress. Our workExpand
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Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.
Malignant peripheral nerve sheath tumors (MPNST) are highly resistant sarcomas that occur in up to 13% of individuals with neurofibromatosis type I (NF1). Genomic analysis of longitudinally collectedExpand
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Transcript Abundance of Phytoene Synthase 1 and Phytoene Synthase 2 Is Associated with Natural Variation of Storage Root Carotenoid Pigmentation in Carrot
Carotenoids are isoprenoid compounds synthesized in plants that serve as photoprotectants essential for photosynthesis and provide plant tissues with red, orange, and yellow pigmentation. TheseExpand
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