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Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection.
TLDR
Since the introduction of HAART, there has been a significantly increased risk of NADCs, which has now stabilized, and a number of factors are associated with this increased risk, including HAART use.
British HIV Association guidelines for the treatment of HIV‐1‐positive adults with antiretroviral therapy 2012
TLDR
These guidelines are aimed at clinical professionals directly involved with and responsible for the care of adults with HIV infection and at community advocates responsible for promoting the best interests and care of HIV-positive adults.
EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients.
TLDR
EMA/CO is an effective and well-tolerated regimen for high-risk GTT and more than half of the women will retain their fertility; however, there is a small but significant risk of second malignancy.
A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
TLDR
An analysis of a series of leukaemic patients carrying t(4;11 and t(9;11) translocations indicate that the majority of breakpoints in infant leukaemias lie within a 5 kb region.
Clinical Features and Outcome in HIV-Associated Multicentric Castleman's Disease.
TLDR
The outlook has improved dramatically in recent years with the introduction of rituximab-based therapy and yields high overall survival rates, and HIV-associated MCD is a remitting-relapsing disease.
Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma.
TLDR
In the clinical experience HAART could be successfully continued in those with IRIS-associated KS, and in patients with higher CD4 counts, KS-associated edema, and therapy with both protease inhibitors and non-nucleosides together.
Fifty years of multicentric Castleman's disease
TLDR
Systemic treatments for Castleman's disease have included chemotherapy, anti-herpesvirus treatments to reduce the KSHV viral load, highly active antiretroviral therapy (HAART) to reduce HIV viraemia and latterly monoclonal antibodies against both IL 6 and CD20.
HIV-Associated Anal Cancer: Has Highly Active Antiretroviral Therapy Reduced the Incidence or Improved the Outcome?
TLDR
Unlike other HIV-associated cancers, there has been no significant change in the incidence, clinical features, or overall survival since the introduction of HAART.
Kaposi sarcoma
TLDR
Kaposi sarcoma is a rare cancer that typically presents with multiple pigmented skin lesions, but may take an aggressive course characterised by lesion ulceration, oedema and visceral organ involvement.
Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas.
TLDR
Among patients receiving chemotherapy for solid tumors or lymphoma, the prophylactic use of levofloxacin reduces the incidence of fever, probable infection, and hospitalization.
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