• Publications
  • Influence
The mouse light/dark box test.
The light/dark test is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behaviour of rodents in response to mild stressors, that is, novelExpand
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Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
The present study was designed to evaluate the roles of 5-HT2 and 5-HT3 receptors in the mouse forced swimming test, by using selective agonists and antagonists of 5-HT(2A/C) and 5-HT3 receptorExpand
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Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
Risperidone is a relatively new antipsychotic drug that has been reported to improve both the positive and the negative symptoms of schizophrenia and produces relatively few extrapyramidal sideExpand
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The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
Despite significant advances in pharmacologic therapy of depression over the past two decades, a substantial proportion of patients fail to respond or experience only partial response to serotoninExpand
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Antidepressant-like effects in various mice strains in the forced swimming test
RationaleStrain differences in mice have been reported in response to drugs in the mouse forced swimming test (FST), even if few antidepressants were examined.ObjectivesThe aim of the present studyExpand
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3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
The 3,4-methylenedioxy analogues of amphetamine [MDMA ("Ecstasy", "Adam"), MDA ("Love") and MDE ("Eve")] are recreational drugs that produce feelings of euphoria and energy and a desire to socialize,Expand
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Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial.
BACKGROUND Despite several treatmentoptions, adherenceto therapy is poor in patients with bipolar disorder. AIMS A double-blind, controlled comparison of aripiprazole and haloperidol in patientsExpand
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Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors.
OBJECTIVE To study agomelatine (S 20098), a potent agonist at melatonin receptors and antagonist at serotonin-2C (5-HT(2C)) receptors, in an animal model of depression, namely, the rodent forcedExpand
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Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
  • M. Berk, S. Dodd, +4 authors T. Norman
  • Psychology, Medicine
  • Acta psychiatrica Scandinavica. Supplementum
  • 1 October 2007
Objective:  Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder.Expand
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How valuable are animal models in defining antidepressant activity?
Animal models of depression have been utilised to screen novel compounds with antidepressant potential although uncertainty lingers concerning their clinical relevance. In order for a model to beExpand
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