The mouse light/dark box test.
Forced swimming test in mice: a review of antidepressant activity
The FST is a good screening tool with good reliability and predictive validity, and CD-1 seems to be the most useful strain for screening purposes, but this needs to be confirmed with some spontaneous locomotor activity studies.
Antidepressant-like effects in various mice strains in the forced swimming test
- D. David, Caroline E. Renard, P. Jolliet, M. Hascöet, M. Bourin
- Psychology, BiologyPsychopharmacology
- 25 February 2003
The FST results have shown that Swiss mice are the most sensitive strain to detect 5-HT and/or NA treatment, and showed that drug sensitivity is genotype dependent.
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
- J. Fang, M. Bourin, G. Baker
- Chemistry, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 25 January 1999
The formation of 9-Hydroxyrisperidone is highly correlated with testosterone 6β-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of ris peridone in rat.
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
There is evidence to suggest that antidepressants that enhance noradrenergic and dopaminergic activity may afford a therapeutic advantage over serotonergic antidepressants in the treatment of symptoms associated with a reduction in positive affect.
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model, but there is a wealth of converging data on the role of dopamine, and the possibility of a dopamine hypothesis for bipolar disorder is examined.
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
Paroxetine: a review.
Paroxetine is well tolerated and effective in the treatment of both depressive and anxiety disorders across the age range and by comparison with tricyclic antidepressants (TCAs) has, therefore, a reduced propensity to cause central and autonomic side effects.
How valuable are animal models in defining antidepressant activity?
Although animal models of depression fail to be unequivocally valid, they represent the best tool to define potential antidepressant activity of drugs, to investigate their mechanism of action and, to a greater extent, explore this complex heterogeneous illness.