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The mouse light/dark box test.
The light/dark test may be useful to predict anxiolytic-like or anxiogenic-like activity in mice, and has the advantages of being quick and easy to use, without requiring the prior training of animals.
Forced swimming test in mice: a review of antidepressant activity
The FST is a good screening tool with good reliability and predictive validity, and CD-1 seems to be the most useful strain for screening purposes, but this needs to be confirmed with some spontaneous locomotor activity studies.
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
The results of the present study suggested that, in the forced swimming test, the selective serotonin reuptake inhibitors act partially through 5-HT3 receptor sites, whereas the tricyclic antidepressants exert effects at 5- HT(2A/C) receptor sites.
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
- J. Fang, M. Bourin, G. Baker
- Chemistry, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 25 January 1999
The formation of 9-Hydroxyrisperidone is highly correlated with testosterone 6β-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of ris peridone in rat.
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
- D. Nutt, K. Demyttenaere, +5 authors S. Stahl
- Psychology, MedicineJournal of psychopharmacology
- 1 July 2007
There is evidence to suggest that antidepressants that enhance noradrenergic and dopaminergic activity may afford a therapeutic advantage over serotonergic antidepressants in the treatment of symptoms associated with a reduction in positive affect.
Antidepressant-like effects in various mice strains in the forced swimming test
- D. David, C. E. Renard, P. Jolliet, M. Hascöet, M. Bourin
- Medicine, PsychologyPsychopharmacology
- 25 February 2003
The FST results have shown that Swiss mice are the most sensitive strain to detect 5-HT and/or NA treatment, and showed that drug sensitivity is genotype dependent.
How valuable are animal models in defining antidepressant activity?
Although animal models of depression fail to be unequivocally valid, they represent the best tool to define potential antidepressant activity of drugs, to investigate their mechanism of action and, to a greater extent, explore this complex heterogeneous illness.
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
- K. Hegadoren, G. Baker, M. Bourin
- Medicine, PsychologyNeuroscience & Biobehavioral Reviews
- 1 March 1999
This review examines the relevant human and animal literature to delineate the possible risks MDMA, MDA and MDE engender with oral consumption in humans and discusses toxicity, psychopathology, neurotoxicity, abuse potential and the potential for drug-drug interactions associated with acute and chronic use.
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
- M. Berk, S. Dodd, +4 authors T. Norman
- Psychology, MedicineActa psychiatrica Scandinavica. Supplementum
- 1 October 2007
Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model, but there is a wealth of converging data on the role of dopamine, and the possibility of a dopamine hypothesis for bipolar disorder is examined.
Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety
- B. N. Dhonnchadha, M. Bourin, M. Hascöet
- Medicine, PsychologyBehavioural Brain Research
- 18 March 2003
Behavioural results are indicative of an anxiolytic-like action of 5-HT(2) receptor agonists, an anxiogenic-like effect of 5 (2A) receptor antagonism, whereas the blockade of 5(2C) receptors are without effect in the mouse models studied.