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Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling
TLDR
Comparative miRNA profiling revealed a set of miRNAs that imply causality between miRNA depletion and spontaneous cardiac remodeling that indicate that modifications in miRNA biogenesis affect both juvenile and adult myocardial morphology and function. Expand
Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus.
TLDR
The aim of this mini-review is to assess to what extent MGO is related to vascular complications in diabetes. Expand
Cooperative Synergy between NFAT and MyoD Regulates Myogenin Expression and Myogenesis*
TLDR
The combined findings provide a novel transcriptional paradigm for the first steps of myogenesis, where a calcineurin/NFATc3 pathway regulates myogenin induction in cooperation with MyoD during myogenesis. Expand
NFATc2 Is a Necessary Mediator of Calcineurin-dependent Cardiac Hypertrophy and Heart Failure*
TLDR
A major role for the NFATc2 transcription factor in pathological cardiac remodeling and heart failure is revealed and the original hypothesis that calcineurin mediates myocyte hypertrophy through activation of NFAT transcription factors is validated. Expand
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure
TLDR
It is reported that increased calcineurin/Nfat signalling and decreased miR-25 expression integrate to re-express the basic helix-loop-helix (bHLH) transcription factor dHAND (also known as Hand2) in the diseased human and mouse myocardium. Expand
The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation.
TLDR
A mechanism whereby miR-199a∼214 actively represses cardiac PPARδ expression is suggested, facilitating a metabolic shift from predominant reliance on fatty acid utilization in the healthy myocardium toward increased reliance on glucose metabolism at the onset of heart failure. Expand
MEF2 Activates a Genetic Program Promoting Chamber Dilation and Contractile Dysfunction in Calcineurin-Induced Heart Failure
TLDR
These findings assign a novel function to MEF2 transcription factors in the postnatal heart, where they activate a genetic program that minimally affects cardiac growth yet promotes chamber dilation, mechanical dysfunction, and dilated cardiomyopathy. Expand
Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma
TLDR
This study provides a comprehensive validation of miR-7 as novel anti-angiogenic therapeutic miRNA that can be systemically delivered to both EC and tumor cells and offers promise for miR -7 as Novel anti-tumor therapeutic. Expand
Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination
TLDR
Self-assembling peptide based systems increase the immunogenicity of peptide epitope vaccines and therefore warrants further development toward clinical use. Expand
Strong in vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds.
TLDR
It is demonstrated that conjugation of antigens to nanogels via reducible covalent bonds for intracellular delivery is a promising strategy to induce effective antigen-specific immune responses against cancer. Expand
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