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Correction for Gobbi et al., Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
- G. Gobbi, F. Bambico, D. Piomelli
- BiologyProceedings of the National Academy of Sciences…
- 18 December 2005
It is shown that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress
Monoamine oxidase inactivation: from pathophysiology to therapeutics.
Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
A role of anandamide in the regulation of emotion is supported and the an andamide transport system is pointed to as a potential target for anxiolytic drugs.
Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates
Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.
NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression
The findings suggest that the role of MAO A in pathological aggression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical function of this receptor in the molecular bases of antisocial personality.
Modulation of Neuropathic and Inflammatory Pain by the Endocannabinoid Transport Inhibitor AM404 [N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]
- G. La Rana, R. Russo, A. Calignano
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 June 2006
The results provide new evidence for a role of the endocannabinoid system in pain modulation and point to anandamide transport as a potential target for analgesic drug development.
Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice
MAO-ANeo mice showed a unique set of behavioral abnormalities, encompassing reduced open-field locomotion, perseverative responses, and a lack of anxiety-like behaviors in the elevated plus-maze and light–dark box paradigms, indicating that MAO A hypomorphism results in behavioral and morphological alterations distinct from those featured by MAO-A KO mice.