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TREK‐1, a K+ channel involved in polymodal pain perception
TLDR
It is demonstrated that TREK‐1 qualifies as one of the molecular sensors involved in pain perception and as an attractive target for the development of new analgesics.
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Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
TLDR
The results indicate that alterations in the functioning, regulation or both of the TREK-1 channel may alter mood, and that this particular K+ channel may be a potential target for new antidepressants.
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The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception
TLDR
The mechano‐gated and highly temperature‐sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated, important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs.
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KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
TLDR
The interaction of KCNE2 with the KCNQ1 subunit is demonstrated, which results in a drastic change of KCnQ1 current amplitude and gating properties, andKCNE2 mutations also reveal their specific functional consequences on KCNq1 currents.
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p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK‐1
TLDR
It is demonstrated that association with p11 is essential for trafficking of TASK‐1 to the plasma membrane and masks an endoplasmic reticulum retention signal identified as Lys‐Arg‐Arg that precedes the Ser‐Ser‐Val sequence.
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The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3
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Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant.
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M‐type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit
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Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization.
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Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo
View on Elsevier
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