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The versatility and universality of calcium signalling
The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Calcium: Calcium signalling: dynamics, homeostasis and remodelling
- M. Berridge, M. Bootman, H. Roderick
- Environmental Science, BiologyNature reviews. Molecular cell biology
- 1 July 2003
The Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics and has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
Calcium - a life and death signal
This research investigates how the calcium ion regulates cell birth, life and death, and how it regulates so many different cellular processes in the human body.
2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca2+ entry but an inconsistent inhibitor of InsP3‐induced Ca2+ release
- M. Bootman, T. Collins, L. Mackenzie, H. Roderick, M. Berridge, C. Peppiatt
- Biology, ChemistryThe FASEB Journal
- 1 August 2002
2‐Aminoethoxydiphenyl borate is a reliable blocker of store‐operated Ca2+ entry but an inconsistent inhibitor of InsP3‐induced Ca 2+ release.
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
The anti-apoptotic protein Bcl-2 significantly inhibited InsP3-mediated calcium release and elevation of cytosolic calcium in WEHI7.2 T cells because responses to both anti-CD3 antibody and a cell-permeant InsP 3 ester were decreased.
Calcium signalling--an overview.
To generate the variety of observed Ca2+ signals, different cell types employ components selected from aCa2+ signalling 'toolkit', which comprizes an array of signalling, homeostatic and sensory mechanisms.
Calcium Signalling: More Messengers, More Channels, More Complexity
Imaging the hierarchical Ca2+ signalling system in HeLa cells.
The hierarchy of Ca2+ signalling events, from fundamental levels (blips) to intermediate levels (puffs) to Ca2- waves, is a prototype forCa2+ signal transduction for non‐excitable cells, and is also analogous to the Ca2+.
Mitochondria are morphologically and functionally heterogeneous within cells
The data indicate that mitochondria within individual cells are morphologically heterogeneous and unconnected, allowing them to have distinct functional properties.