• Publications
  • Influence
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Nitrogen dioxide and carbonate radical anion have received sporadic attention thus far from biological investigators. However, accumulating data on the biochemical reactions of nitric oxide and itsExpand
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Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria
Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show,Expand
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Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon Dioxide*
The biological effects of peroxynitrite have been recently considered to be largely dependent on its reaction with carbon dioxide, which is present in high concentrations in intra- and extracellularExpand
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The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy?
The oxidation of 2',7'-dichlorofluorescin (DCFH) and its diacetate form (DCFHDA) by the HRP/peroxynitrite system was investigated. Both DCFH and DCFHDA were oxidized to fluorescent products. A majorExpand
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MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to affect cellular signaling. Here, weExpand
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Male infertility: a public health issue caused by sexually transmitted pathogens
Sexually transmitted diseases (STDs) are caused by several pathogens, including bacteria, viruses and protozoa, and can induce male infertility through multiple pathophysiological mechanisms.Expand
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Redox regulation of NF‐κB p50 and M1 polarization in microglia
Redox‐signaling is implicated in deleterious microglial activation underlying CNS disease, but how ROS program aberrant microglial function is unknown. Here, the oxidation of NF‐κB p50 to a freeExpand
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Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases.
The Ras superfamily of small GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. While the basicExpand
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Mitochondria and arrhythmias.
Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the incessant electrical activity and contractile action of cardiac muscle. Emerging evidence indicates thatExpand
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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
  • H. Tang, J. Chen, +11 authors J. Yuan
  • Biology, Medicine
  • American journal of physiology. Lung cellular and…
  • 15 January 2015
Pulmonary vascular remodeling, mainly attributable to enhanced pulmonary arterial smooth muscle cell proliferation and migration, is a major cause for elevated pulmonary vascular resistance andExpand
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