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Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis.
PPIs exacerbate NSAID-induced intestinal damage at least in part because of significant shifts in enteric microbial populations, and prevention or reversal of this dysbiosis may be a viable option for reducing the incidence and severity of NSAID enteropathy.
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.
By interfering with the inhibitory enzymatic activities of myeloid cells, orally administered NO aspirin normalized the immune status of tumor-bearing hosts, increased the number and function of tumors-antigen-specific T lymphocytes, and enhanced the preventive and therapeutic effectiveness of the antitumor immunity elicited by cancer vaccination.
Leukotrienes: lipid bioeffectors of inflammatory reactions.
These potent lipid bioeffectors are synthesized during the course of inflammatory reactions and their pharmacological modulation is able to significantly attenuate the clinical manifestations associated with different inflammatory pathologies.
Therapeutic potential of nitrate esters of commonly used drugs.
The approach and the possibility of generating new chemical entities, combining well-known drugs with an NO-donating moiety in order to increase activity and safety, are described, along with examples of their activity and potential therapeutic application in different pathologies.
Release of Leukotriene A4 Versus Leukotriene B4 from Human Polymorphonuclear Leukocytes*
The objective of this study was to determine the relative amount of leukotriene A4 synthesized by human polymorphonuclear leukocytes (PMNL) that is available for transcellular biosynthetic processes, and it was demonstrated that in human PMNL, the relative amounts of nonenzymatic versus enzymatic leuko A4-derived metabolites increased with decreasing cell concentrations.
Modulation of COX-2 Expression by Statins in Human Aortic Smooth Muscle Cells
It is demonstrated that statins up-regulate COX-2 expression and subsequent prostacyclin formation in human aortic smooth muscle cells in part through inhibition of Rho.
p38 Mitogen-Activated Protein Kinase Activation Is Required for Thromboxane- Induced Contraction in Perfused and Pressurized Rat Mesenteric Resistance Arteries
New insights are brought in the transduction pathway involved in the contractile response of resistance arteries to TxA2/endoperoxide receptor stimulation that requires p38 MAPK activation, but did not involve ERK1/2 MAPKactivation although both were activated.
Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis.
NO-Donating Aspirin and Aspirin Partially Inhibit Age-Related Atherosclerosis but Not Radiation-Induced Atherosclerosis in ApoE Null Mice
The development and characteristics of radiation-induced atherosclerosis varied between different arteries but could not be circumvented by anti-inflammatory and anti-coagulant therapies.
Nitric oxide-donating aspirin (NCX 4016): an overview of its pharmacological properties and clinical perspectives
The pharmacological profile of the NO-donating aspirin, NCX 4016, has been shown to retain the anti-inflammatory properties of aspirin and therefore possesses the same efficacy as aspirin in animal models of pain and inflammation and cardiovascular models.