• Publications
  • Influence
Release of Leukotriene A4 Versus Leukotriene B4 from Human Polymorphonuclear Leukocytes*
The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid, leukotriene A4, is known to be released from cells and subsequently taken up by other cells for biochemicalExpand
  • 88
  • 3
Leukotrienes: lipid bioeffectors of inflammatory reactions.
The leukotrienes arise from oxidative metabolism of arachidonic acid through the action of the 5-lipoxygenase enzyme, leading to the unstable allylic epoxide leukotriene A4. This intermediateExpand
  • 56
  • 3
Therapeutic potential of nitrate esters of commonly used drugs.
Organic nitrates, such as nitroglycerin, have been used in clinical practice for more than one century for the treatment of angina, even before the identification of Nitric Oxide (NO) as theExpand
  • 26
  • 3
Modulation of COX-2 Expression by Statins in Human Aortic Smooth Muscle Cells
Cyclooxygenase (COX)-2 and COX-1 play an important role in prostacyclin production in vessels and participate in maintaining vascular homeostasis. Statins are inhibitors of 3-hydroxy-3-methylglutarylExpand
  • 96
  • 2
  • PDF
Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent.
Cysteine-containing leukotrienes (cysteinyl-LTs) are potent bronchoconstrictors and play a key role in asthma. We found that histamine and LTD4 markedly constrict strips of human bronchi (HB) withExpand
  • 36
  • 2
Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells.
  • A. Bonazzi, M. Bolla, +10 authors A. Sala
  • Biology, Medicine
  • American journal of respiratory and critical care…
  • 1 December 2000
We studied the effect of endogenous and exogenous prostaglandin E(2) (PGE(2)), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 beta-induced COX-2Expand
  • 48
  • 1
  • PDF
Pro-apoptotic effect of a nitric oxide-donating NSAID, NCX 4040, on bladder carcinoma cells
Nitric oxide-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs) are a promising class of compounds that cause cell cycle perturbations and induce apoptosis in cell lines from differentExpand
  • 34
  • 1
In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines
BackgroundNitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novelExpand
  • 30
  • 1
Nitrosulindac (NCX 1102): A new nitric oxide‐donating non‐steroidal anti‐inflammatory drug (NO‐NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines
The aim of our study was to explore the anti‐tumoral potential of the Nitric Oxide‐Donating Non‐Steroidal Anti‐Inflammatory Drugs (NO‐NSAID) NCX1102 (nitrosulindac), on three human prostaticExpand
  • 29
  • 1