Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates
- Brandon K. Tan, M. Bogdanov, Jinshi Zhao, W. Dowhan, C. Raetz, Z. Guan
- Biology, ChemistryProceedings of the National Academy of Sciences
- 17 September 2012
The combined YmdB-ClsC gene pair used PE as the phosphatidyl donor to PG to form CL, which demonstrates a third and unique mode for CL synthesis.
Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesis.
- M. Bogdanov, Wei Zhang, Jun Xie, W. Dowhan
- Biology, ChemistryMethods
- 1 June 2005
Lipid-dependent membrane protein topogenesis.
- W. Dowhan, M. Bogdanov
- BiologyAnnual Review of Biochemistry
- 2 June 2009
The membrane translocation potential of negative amino acids working in opposition to the positive-inside rule is largely dampened by the normal presence of phosphatidylethanolamine, thus explaining the dominance of positive residues as retention signals.
A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition
- M. Bogdanov, Phil Heacock, W. Dowhan
- Biology, ChemistryEMBO Journal
- 1 May 2002
Results demonstrate that membrane protein topology once attained can be changed in a reversible manner in response to alterations in phospholipid composition, and may be subject to postâassembly proofreading to correct misfolded structures.
Diversity and versatility of lipid-protein interactions revealed by molecular genetic approaches.
- W. Dowhan, E. Mileykovskaya, M. Bogdanov
- Biology, ChemistryBiochimica et Biophysica Acta
- 3 November 2004
Lipid-assisted Protein Folding*
- M. Bogdanov, W. Dowhan
- BiologyJournal of Biological Chemistry
- 24 December 1999
The role individual lipids play as part of the protein folding machinery has been largely ignored and the factors and mech-anism driving correct folding of integral membrane proteins arelargely unknown.
To flip or not to flip: lipidâprotein charge interactions are a determinant of final membrane protein topology
- M. Bogdanov, Jun Xie, Phil Heacock, W. Dowhan
- BiologyJournal of Cell Biology
- 8 September 2008
Evidence is presented that final topology is influenced by lipidâprotein interactions most likely outside of the translocon, which explains the dominance of positive over negative amino acids as co- or post-translational topological determinants.
The Osmotic Activation of Transporter ProP Is Tuned by Both Its C-terminal Coiled-coil and Osmotically Induced Changes in Phospholipid Composition*
- Y. Tsatskis, Jumana Khambati, M. Dobson, M. Bogdanov, W. Dowhan, J. M. Wood
- Biology, ChemistryJournal of Biological Chemistry
- 16 December 2005
The proportion of cardiolipin in a polar lipid extract from E. coli increased with extracellular osmolality so that the osmlality activating ProPEc was a direct function of membrane cardioline content, which contributes to ProP adaptation by altering bulk membrane properties or by acting as a ProP ligand.
Lipids in the assembly of membrane proteins and organization of protein supercomplexes: implications for lipid-linked disorders.
- M. Bogdanov, E. Mileykovskaya, W. Dowhan
- Biology, ChemistrySub-cellular biochemistry
- 2008
Understanding the principles governing lipid-dependent assembly and organization of membrane proteins and protein complexes will be useful in developing novel therapeutic approaches for disorders in which lipids play an important role.
Lipids and topological rules governing membrane protein assembly.
- M. Bogdanov, W. Dowhan, H. Vitrac
- BiologyBiochimica et Biophysica Acta
- 1 August 2014
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