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Carolacton – A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated Bacterium Streptococcus mutans†
TLDR
The macrolide ketocarbonic acid carolacton was discovered to be a highly potent agent against biofilms containing the caries- and endocarditis-associated bacterium Streptococcus mutans and the 2D structure of 1 was elucidated by HRMS, IR and 2D NMR spectroscopy.
Generalized Voronoi Tessellation as a Model of Two-dimensional Cell Tissue Dynamics
TLDR
A consistent theoretical framework of multiplicatively weighted distance functions is developed, defining generalized finite Voronoi neighborhoods around cell bodies of varying radius, which serve as heterogeneous generators of the resulting model tissue.
Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum.
Since 1993, when the World Health Organization declared tuberculosis “a global health emergency”, there has been new impetus to research on tuberculosis because it can no longer be sufficiently
Total and semi-syntheses of antimicrobial thuggacin derivatives.
TLDR
Exchanging the C17-C25 side chain for simplified hydrophobic chains led to complete loss of antibacterial activity, and exchange of the thiazole by an oxazole ring or removal of the hexyl side chain at C2 had no substantial effect on the biological properties.
Total synthesis of thuggacin B.
Coupling of cytoplasm and adhesion dynamics determines cell polarization and locomotion
TLDR
An alternative and self-organizational model incorporating polymerization, pushing and sliding of filaments, as well as formation of adhesion sites and their force dependent kinetics can be combined into a non-linearly coupled system of hyperbolic, parabolic and elliptic differential equations.
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