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Gastrulation in the mouse: The role of the homeobox gene goosecoid
TLDR
Mouse goosecoid-expressing cells are found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Expand
Cilia-Driven Leftward Flow Determines Laterality in Xenopus
TLDR
It is shown that a cilia-driven leftward flow precedes asymmetric nodal expression in the frog Xenopus and injection of 1.5% methylcellulose into the archenteron preventedleftward flow and resulted in laterality defects, demonstrating that the flow itself was required for asymmetric gene expression and organ placement. Expand
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
TLDR
A role for Pitx2 is suggested in promoting looping of the linear heart and gut in mouse, frog and zebrafish embryos and in Xenopus when these organs undergo asymmetric looping morphogenesis. Expand
The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4
TLDR
It is reported that follistatin antagonizes the activities of BMP-4 in frog embryos and mouse teratocarcinoma cells, and it is shown that the follistatins and B MP-4 proteins can interact directly in vitro. Expand
Cell Movements at Hensen’s Node Establish Left/Right Asymmetric Gene Expression in the Chick
TLDR
It is shown that asymmetric cell rearrangements take place within chick embryos, creating a leftward movement of cells around the node, which represents an alternative strategy for breaking L/R symmetry in gene activity. Expand
The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice
TLDR
H homozygous mutant embryos showed right pulmonary isomerism, randomization of embryonic turning, heart looping, and abdominal situs, and normal levels of Foxa2 and shh were expressed, suggesting that polycystin-2 acts downstream or in parallel to shh and upstream of the nodal cascade. Expand
Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death.
TLDR
Although the observed phenotype is in accordance with the late expression domains of goosecoid in wild-type embryos, it is suggested that the lack of an earlier phenotype is the result of functional compensation by other genes. Expand
The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus
TLDR
Coco acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline. Expand
Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor Shox2 in Sinoatrial and Pacemaking Development
TLDR
A critical function of Shox2 is postulated in the recruitment of sinus venosus myocardium comprising the sinoatrial nodal region and the venous valves, which is crucial for a comprehensive mechanistic understanding of arrhythmia-related diseases. Expand
Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left–right asymmetry
TLDR
Pitx2c thus represents the left-specific isoform involved in vertebrate left-right asymmetry, suggesting a maintenance mechanism following the down-regulation of nodal in the l-LPM. Expand
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