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Presence of endothelial progenitor cells, distinct from mature endothelial cells, within human CD146+ blood cells.
TLDR
This study establishes that, beside CECs, CD146+ circulating cells contain a subpopulation of EPCs with potential use in proangiogenic therapy, and offers a promising tool for monitoring vascular injury/regeneration processes in clinical situations. Expand
Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells.
TLDR
It is concluded that hypoxia induced a downregulation of expression and activity of epithelial Na channels and Na,K-ATPase in alveolar cells and this was associated with complete functional recovery. Expand
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.
TLDR
Cross-talk between the nongenomic and genomic responses to aldosterone in renal cells is suggested and it is suggested that the ald testosterone-MR mediated increase in mRNA/protein synthesis and ion transport depends, at least in part, upon PKCalpha activation. Expand
Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.
TLDR
It is established that hypoxia-induced inhibition of amiloride-sensitive sodium channel activity is mediated by decreased apical expression of ENaC subunits and that beta(2)-agonists reverse this effect by enhancing the insertion of ENc subunits into the membrane of hypoxic alveolar epithelial cells. Expand
Characterization of Rat NDRG2 (N-Myc Downstream Regulated Gene 2), a Novel Early Mineralocorticoid-specific Induced Gene*
TLDR
Results indicate that NDRG2 regulation by aldosterone is an early mineralocorticoid-specific effect, and Interestingly, N DRG2 is homologous to Drosophila MESK2, a component of the Ras pathway, suggesting that activation of the Rash cascade may play a significant role in mineraloc Corticoid signaling. Expand
CD146 and its Soluble Form Regulate Monocyte Transendothelial Migration
TLDR
The results demonstrate that CD146 is regulated by the inflammatory cytokine TNF and thatCD146 and sCD146 are both involved in monocyte transendothelial migration during inflammation. Expand
Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.
TLDR
Distinct distribution of 4.1 proteins along the nephron suggests their involvement in targeting of selected transmembrane proteins in kidney epithelium and, therefore, in regulation of specific kidney functions. Expand
Transcriptional Regulation of Sodium Transport by Vasopressin in Renal Cells*
TLDR
The amounts of mRNA encoding the α1 (not β1) subunit of Na+/K+-ATPase and the β and γ subunits of the amiloride-sensitive epithelial Na+ channel were significantly increased by AVP treatment, suggesting a Na+-independent increase in the rate of transcription of these subunits. Expand
Hypoxia and β2-Agonists Regulate Cell Surface Expression of the Epithelial Sodium Channel in Native Alveolar Epithelial Cells*
TLDR
It is established that hypoxia-induced inhibition of amiloride-sensitive sodium channel activity is mediated by decreased apical expression of ENaC subunits and that β2-agonists reverse this effect by enhancing the insertion of ENc subunits into the membrane of hypoxic alveolar epithelial cells. Expand
Characteristics and regulation of 11 beta-hydroxysteroid dehydrogenase of proximal and distal nephron.
TLDR
It is concluded that 11-HSD in the CCD and PR differs by its Vmax and cofactor dependence, whereas in PR dehydrogenase and reductase activity were found. Expand
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